SML0196
雷西莫特
≥98% (HPLC), powder, TLR7/TLR8 agonist
别名:
4-氨基-2-(乙氧基甲基)-α, R-848, R848, S28463, α-二甲基-1H-咪唑并(4,5-c)喹啉-1-乙醇
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C17H22N4O2
化学文摘社编号:
分子量:
314.38
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
雷西莫特, ≥98% (HPLC)
SMILES string
CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
InChI
1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
InChI key
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white to tan
solubility
DMSO: 10 mg/mL, clear (warmed to 60 °C)
shipped in
wet ice
storage temp.
−20°C
Quality Level
相关类别
Application
瑞喹莫德已用于刺激骨髓源性树突状细胞(BMDC)(和B细胞。它也被用作恶性黑色素瘤细胞系B16F10中Toll样受体(TLR7)的配体。
雷西莫特可用于免疫学和癌症相关的细胞信号传导研究。
Biochem/physiol Actions
瑞喹莫德是314.4 Da分子，可在 L. infantum Sp内脏感染期间引发免疫功能。它可以介导粒细胞、巨噬细胞、白细胞和树突状细胞的运输。它是治疗皮肤肿瘤的建议外敷药物，例如光化性角化病(AK)和表浅性基底细胞癌。
雷西莫特(R-848)是一种有效的TLR7/TLR8合成激动剂，具有抗病毒和抗肿瘤活性。
雷西莫特属于咪唑喹啉胺类化合物，具有免疫调节作用。雷西莫特可提高细胞因子的水平，如TNF-α、IL-6和IFN-α。
雷西莫特是toll样受体7和8（TLR-7和TLR-8）的激动剂。
Features and Benefits
《受体分类和信号转导》手册的 细胞因子受体（白细胞介素-1受体/TIR家族） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
D H Dockrell et al.
The Journal of antimicrobial chemotherapy, 48(6), 751-755 (2001-12-06)
Augmenting the host's natural immune response to viruses by the administration of exogenous cytokines such as interferon-alpha (IFN-alpha) is a strategy increasingly employed in antiviral therapeutics. Enhancing the release of endogenous cytokines is, however, an alternative approach. The imidazoquinolinamines imiquimod
Matthew S Block et al.
Melanoma research, 29(4), 420-427 (2018-12-07)
A vaccine that could expand melanoma-specific T cells might reduce the risk of recurrence of resected melanoma and could provide an alternative or adjunct to standard immunotherapy options. We tested the safety and immunogenicity of a vaccine coupling a melanoma-associated
Resiquimod, a topical drug for viral skin lesions and skin cancer
Meyer T, et al.
Expert Opinion on Investigational Drugs, 22(1), 149-159 (2013)
Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells
Meng Y, et al.
International Journal of Molecular Medicine, 39(5), 1101-1110 (2017)
AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles
Losier TT, et al.
Cell Reports, 26(8), 2150-2165 (2019)
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持