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Merck
CN

SML0174

Sigma-Aldrich

GPR35 Agonist, Compound 10

≥98% (HPLC)

别名:

2-[4-[(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid

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About This Item

经验公式(希尔记法):
C12H9NO5S
分子量:
279.27
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥5 mg/mL at ~60 °C

储存温度

2-8°C

SMILES字符串

OC(=O)COc1ccc(cc1)\C=C2/SC(=O)NC2=O

InChI

1S/C12H9NO5S/c14-10(15)6-18-8-3-1-7(2-4-8)5-9-11(16)13-12(17)19-9/h1-5H,6H2,(H,14,15)(H,13,16,17)/b9-5-

InChI key

WXMCOLGPDOYHNK-UITAMQMPSA-N

应用

GPR35 Agonist, Compound 10, may be used in GPR35-mediated cell signaling studies.

生化/生理作用

GPR35 agonist Compound 10 is a GPR35 agonist the binds with higher affinity than other known agonists, such as kynurenic acid and zaprinast. Compound 10 was more potent than zaniprast (pEC50 = 5.3 vs 4.18) for recombinantly expressed human GPR35, and unlike zaprinast, is equipotent for human and rat GPR35

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Ida Marie Modvig et al.
American journal of physiology. Endocrinology and metabolism, 320(5), E874-E885 (2021-03-02)
The aim of this study was to explore individual amino acid-stimulated GLP-1 responses and the underlying stimulatory mechanisms, as well as to identify the amino acid-sensing receptors involved in amino acid-stimulated GLP-1 release. Experiments were primarily based on isolated perfused

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