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质量水平
检测方案
≥98% (HPLC)
形式
powder
旋光性
[α]/D -55 to -70°, c = 1 in methanol
储存条件
desiccated
颜色
white to tan
溶解性
DMSO: ≥20 mg/mL
创始人
Novartis
储存温度
2-8°C
SMILES字符串
CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
InChI
1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
InChI key
ACWBQPMHZXGDFX-QFIPXVFZSA-N
基因信息
human ... AGTR1(185)
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应用
使用缬沙坦治疗小鼠，以研究Ang II依赖性途径对醛固酮相关作用的影响。
生化/生理作用
缬沙坦是一种血管紧张素II 1型（AT1）受体拮抗剂和抗高血压药。缬沙坦可以防止由血压突然升高导致的心脏病发作和中风。 缬沙坦可降低心脏病发作幸存者的心肌梗死相关并发症。
警示用语：
Warning
危险声明
预防措施声明
危险分类
Repr. 2 - STOT SE 3
靶器官
Central nervous system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Frédéric Michel et al.
Circulation, 109(16), 1933-1937 (2004-04-14)
We analyzed the role of aldosterone in ischemia-induced neovascularization and the involvement of angiotensin II (Ang II) signaling in this effect. Ischemia was induced by right femoral artery ligature in mice treated or not with aldosterone (4.5 microg/day), aldosterone plus
N M Kaplan
American family physician, 60(4), 1185-1190 (1999-10-03)
The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-VI) includes recommendations for the assessment of overall cardiovascular risk and the need for active antihypertensive drug therapy. Once the decision to
Teun van der Bom et al.
Circulation, 127(3), 322-330 (2012-12-19)
The role of angiotensin II receptor blockers in patients with a systemic right ventricle has not been elucidated. We conducted a multicenter, double-blind, parallel, randomized controlled trial of angiotensin II receptor blocker valsartan 160 mg twice daily compared with placebo
Jacob A Udell et al.
Clinical chemistry, 59(6), 959-967 (2013-03-20)
Acute coronary syndrome (ACS) activates neurohormonal pathways, including elevations in circulating aldosterone, with deleterious cardiovascular effects. We aimed to determine if early, more complete renin-angiotensin-aldosterone system inhibition (RAASI) in post-ACS patients without ventricular dysfunction or heart failure would result in
Young In Sohn et al.
Biochemical and biophysical research communications, 439(4), 464-470 (2013-09-10)
Recent studies demonstrated that the antihypertensive drug Valsartan improved spatial and episodic memory in mouse models of Alzheimer's Disease (AD) and human subjects with hypertension. However, the molecular mechanism by which Valsartan can regulate cognitive function is still unknown. Here
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