SML0136
TGN-020
≥98% (HPLC), AQP4 inhibitor, powder
别名:
2-（烟酰胺）-1,3,4-噻二唑, N-（1,3,4-噻二唑-2-基）-3-吡啶甲酰胺, N-（1,3,4-噻二唑-2-基）吡啶-3-甲酰胺, N-（1,3,4-噻二唑）-间-烟酰胺
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关于此项目
经验公式（希尔记法）:
C8H6N4OS
化学文摘社编号:
分子量:
206.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
TGN-020, ≥98% (HPLC)
SMILES string
O=C(Nc1nncs1)c2cccnc2
InChI
1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)
InChI key
AGEGZHOPKZFKBP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥8 mg/mL
storage temp.
room temp
Quality Level
Application
人肺上皮细胞Beas2B经TGN-020处理以研究其他对香烟烟雾提取物诱导的CCN1分泌的影响。
Biochem/physiol Actions
TGN-020是大脑中丰度最高的水通道——水通道蛋白4（AQP4）的抑制剂。水通道蛋白（AQP）是维持流体稳态并使水穿过屏障膜所需的水通道，但它可促进病理性细胞体积变化并引起损伤状态下的水肿。在局灶性脑缺血小鼠模型中，AQP4抑制剂TGN-020的预处理可显著降低与缺血性损伤相关的脑水肿的体积。
水通道蛋白4（AQP4）抑制剂
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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