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Merck
CN
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文件

安全信息

SML0132

Sigma-Aldrich

醋酸兰瑞肽

≥98% (HPLC)

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别名:
3-(2-萘基)-D-丙氨酰基-L-半胱氨酰基-L-酪氨酸-D-色氨酸-L-赖氨酰基-L-戊酰基-L-半胱氨酰-L-苏氨酸酰胺环状(2→7)-乙酸二硫, BIM-23014C, 醋酸血管肽素
经验公式（希尔记法）:
C54H69N11O10S2 · xC2H4O2
CAS号:
127984-74-1
分子量:
1096.32 (free base basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
329825182
NACRES:
NA.25

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to off-white

运输

wet ice

储存温度

−20°C

SMILES字符串

CC(O)=O.CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)NC(=O)[C@H](N)Cc5ccc6ccccc6c5

InChI

1S/C54H69N11O10S2.C2H4O2/c1-29(2)45-54(75)63-44(53(74)65-46(30(3)66)47(57)68)28-77-76-27-43(62-48(69)38(56)23-32-15-18-33-10-4-5-11-34(33)22-32)52(73)60-41(24-31-16-19-36(67)20-17-31)50(71)61-42(25-35-26-58-39-13-7-6-12-37(35)39)51(72)59-40(49(70)64-45)14-8-9-21-55;1-2(3)4/h4-7,10-13,15-20,22,26,29-30,38,40-46,58,66-67H,8-9,14,21,23-25,27-28,55-56H2,1-3H3,(H2,57,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,75)(H,64,70)(H,65,74);1H3,(H,3,4)/t30-,38-,40+,41+,42-,43+,44?,45+,46+;/m1./s1

InChI key

DEXPIBGCLCPUHE-HPDHVNDUSA-N

应用

乙酸兰瑞肽已被用作抑制剂，以测试野生型小鼠中生长激素/甲状腺激素信号转导对硫化氢调节的可变性。

生化/生理作用

醋酸兰瑞肽是一种生长抑素类似物，是生长抑素受体SRIF-1 sst2亚型的选择性激动剂，对sst2的结合亲和力为0.8 nM，对sst5的结合亲和力为5.2 nM，对sst3的结合亲和力为100 nM，对于SRIF-2亚型sst1和sst4受体的结合亲和力为1000 nM以上。它在临床上可用于肢端肥大症和神经内分泌肿瘤所引起的症状的治疗，并且在最近的研究中还可以用于抑制肿瘤的生长，并显示出对非内分泌肿瘤的活性。

象形图

Health hazard
GHS08

警示用语：

Warning

危险声明

H361

预防措施声明

P281

危险分类

Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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