SML0120
哌克昔林 马来酸盐
≥98% (HPLC), CPT-1 inhibitor, powder
别名:
2-(2,2-二环己基乙基)哌啶
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关于此项目
经验公式（希尔记法）:
C19H35N · C4H4O4
化学文摘社编号:
分子量:
393.56
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
229-775-5
MDL number:
产品名称
哌克昔林 马来酸盐, ≥98% (HPLC)
InChI key
JDZOTSLZMQDFLG-BTJKTKAUSA-N
InChI
1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... CPT1B(1375), CPT2(1376), MTOR(2475)
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相关类别
Application
马来酸哌克昔林已用于阻止脂肪酸氧化。它也被用作5′腺苷单磷酸活化蛋白激酶(AMPK)激活剂和蠕虫寿命试验。
马来酸哌克昔林用作蠕虫寿命试验的原料。它还用于阻止脂肪酸氧化。
Biochem/physiol Actions
抗心绞痛代谢调节剂；肉毒碱棕榈酰转移酶抑制剂
马来酸哌克昔林是一种抗心绞痛代谢调节剂。它能够抑制线粒体酶肉毒碱棕榈酰转移酶CPT-1并在较小程度上抑制CPT-2。这导致心肌底物利用从长链脂肪酸转变为碳水化合物，从而使葡萄糖和乳酸利用率增加，并且通过与之前相同的O2消耗而增加ATP产生，从而提高心肌效率。最近还发现马来酸哌克昔林能够抑制mTORC1的活性。
General description
马来酸哌克昔林可调节冠状血管舒张并阻止运动性心动过速。它可用于治疗心绞痛和变异型心绞痛。马来酸哌克昔林是一种心脏代谢剂。它与周围神经病变、颅内高压伴乳头水肿和近端肌病有关。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes
Xu C, et al.
Testing, 25(2), 523-535 (2018)
Ryuichiro Yamamoto et al.
Journal of bone and mineral metabolism, 31(1), 26-33 (2012-09-27)
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic ossification. FOP is caused by a gain-of-function mutation in ACVR1 encoding the bone morphogenetic protein type II receptor, ACVR1/ALK2. The mutant receptor causes upregulation of a
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].
T Kumamoto
Ryoikibetsu shokogun shirizu, (36)(36), 263-266 (2001-10-13)
Ryuta Koishi et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 22(3), 343-350 (2002-05-30)
The novel colony-stimulating factor (CSF) inducer leustroducsin B (LSN-B), which was isolated from Streptomyces platensis, has been shown to have potent cytokine-inducing activities in clonal human bone marrow-derived stromal cell line KM-102 and in primary human bone marrow-derived stromal cells.
[Myopathy caused by perhexiline maleate].
E Gil Néciga et al.
Neurologia (Barcelona, Spain), 2(2), 86-87 (1987-03-01)
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