推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
DMSO: ≥5 mg/mL
储存温度
2-8°C
SMILES字符串
OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
InChI
1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
JDZOTSLZMQDFLG-BTJKTKAUSA-N
基因信息
human ... CPT1B(1375) , CPT2(1376) , MTOR(2475)
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一般描述
马来酸哌克昔林可调节冠状血管舒张并阻止运动性心动过速。它可用于治疗心绞痛和变异型心绞痛。马来酸哌克昔林是一种心脏代谢剂。它与周围神经病变、颅内高压伴乳头水肿和近端肌病有关。
应用
马来酸哌克昔林已用于阻止脂肪酸氧化。它也被用作5′腺苷单磷酸活化蛋白激酶(AMPK)激活剂和蠕虫寿命试验。
马来酸哌克昔林用作蠕虫寿命试验的原料。它还用于阻止脂肪酸氧化。
生化/生理作用
马来酸哌克昔林是一种抗心绞痛代谢调节剂。它能够抑制线粒体酶肉毒碱棕榈酰转移酶CPT-1并在较小程度上抑制CPT-2。这导致心肌底物利用从长链脂肪酸转变为碳水化合物，从而使葡萄糖和乳酸利用率增加，并且通过与之前相同的O2消耗而增加ATP产生，从而提高心肌效率。最近还发现马来酸哌克昔林能够抑制mTORC1的活性。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M A Mariscal et al.
Biochemical pharmacology, 37(18), 3461-3465 (1988-09-15)
The effect of the antianginal agent perhexiline maleate (160 mg/kg i.g., daily for 4 days) on the biliary excretion of sulfobromophthalein (BSP) and BSP-glutathione and the hepatic activity of glutathione S-transferases was investigated in Wistar rats. Perhexiline maleate caused a
Raised intracranial pressure due to perhexiline maleate
Stephens WP, et al.
British Medical Journal, 1(6104), 21-21 (1978)
B D Walker et al.
British journal of pharmacology, 127(1), 243-251 (1999-06-16)
Perhexiline has been used as an anti-anginal agent for over 25 years, and is known to cause QT prolongation and torsades de pointes. We hypothesized that the cellular basis for these effects was blockade of I(Kr). A stable transfection of
B J Foster et al.
Cancer chemotherapy and pharmacology, 22(2), 147-152 (1988-01-01)
The clinical utility of adriamycin in the treatment of patients with metastatic breast cancer is often-limited by the development of drug resistance. It has been recognized that in addition to the development of primary resistance against adriamycin, malignant cells can
V Shacoori et al.
Research communications in chemical pathology and pharmacology, 59(2), 161-172 (1988-02-01)
Human clinical observations and in vivo studies have shown that the amphiphilic drug perhexiline maleate is responsible for lipidosis storage disorders. When the drug was incubated in vivo with rat brain homogenates, the ouabain-sensitive (Na+,K+)-ATPase and the Mg++-ATPase activities were
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