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Merck
CN

SML0117

Sigma-Aldrich

磷苯妥英 二钠盐 水合物

≥98% (HPLC)

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别名:
5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt hydrate
经验公式(希尔记法):
C16H13N2Na2O6P · xH2O
CAS号:
分子量:
406.24 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to tan

溶解性

H2O: ≥15 mg/mL

储存温度

2-8°C

SMILES字符串

O.[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3

InChI

1S/C16H15N2O6P.2Na.H2O/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;;1H2/q;2*+1;/p-2

InChI key

WPAVXKKGWCHUAK-UHFFFAOYSA-L

生化/生理作用

Fosphenytoin is a water soluble phenytoin prodrug.

象形图

Health hazardExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Linda A Steinbaugh et al.
Epilepsy & behavior : E&B, 23(3), 280-284 (2012-02-22)
Continuous electroencephalography (cEEG) is increasingly used to detect both clinical and subclinical seizures in patients with traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH). We assess whether EEG findings predict outcomes in TBI/SAH patients enrolled in a levetiracetam (LEV) vs.
Effect of an educational initiative on physicians' use of weight-based fosphenytoin loading doses in the emergency department.
April D Miller et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(1), 15-16 (2010-01-02)
Advisers recommend improved labeling for phenytoin, fosphenytoin.
Kate Traynor
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(24), 2086-2086 (2010-12-01)
Case 3-2009: a 9-month-old boy with seizures.
Ajit Singh Kashyap et al.
The New England journal of medicine, 360(15), 1572-1572 (2009-04-10)
Clinical pharmacology of parenteral use of antiepileptic drugs.
Meir Bialer
Epilepsia, 48 Suppl 8, 46-48 (2008-03-11)

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