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Merck
CN

SML0101

孟鲁司特 钠 水合物

≥98% (HPLC), CysLT1 receptor antagonist, powder

别名:

1-[[[(1R)-1-[3-[(1E)-2-（7-氯-2-喹啉基）乙烯基] 苯基]-3-[2-（1-羟基-1-甲基乙基）苯基] 丙基] 硫代] 甲基] 环丙烷乙酸 钠盐 水合物

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关于此项目

经验公式（希尔记法）:
C35H35ClNO3S·Na · xH2O
分子量:
608.17 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825159
NACRES:
NA.77
MDL number:
MFCD20527317

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产品名称

孟鲁司特 钠 水合物, ≥98% (HPLC)

SMILES string

O.[Na+].CC(C)(O)c1ccccc1CC[C@@H](SCC2(CC2)CC([O-])=O)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3

InChI

1S/C35H36ClNO3S.Na.H2O/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);;1H2/q;+1;/p-1/b15-10+;;/t32-;;/m1../s1

InChI key

QAXHQHBRRJHZHL-ZPQUALOVSA-M

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +90 to +106° in methanol (c=1)

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥8 mg/mL at 60 °C

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

Quality Level

100

相关类别

Application

孟鲁司特钠水合物已被用作阳性对照药物，用于研究Gumiganghwal-tang水提取物（GGTA）对气道炎症和肺纤维化的保护作用。

Biochem/physiol Actions

孟鲁司特钠水合物是一种白三烯受体拮抗剂（LTRA），用于维持哮喘的治疗和缓解季节性过敏症状。它是亚型特异性CysLT1受体拮抗剂。
孟鲁司特钠水合物是亚型特异性 CysLT1 受体拮抗剂；平喘；抗过敏

Features and Benefits

《受体分类和信号转导》手册的 GABAC受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处了解更多特色 ADME 毒性产品。可访问sigma.com/discover-bsm了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000245579
0000245579
0000174951
0000174950
0000146572

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Aqueous extract of gumiganghwal-tang, a traditional herbal medicine, reduces pulmonary fibrosis by transforming growth Factor beta1/Smad signaling pathway in murine model of chronic Asthma
Jeon WY, et al.
Testing, 11(10), e0164833-e0164833 (2016)
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Identification of the characterization of cysteinyl leukotrienes receptor (CysLTRs) could facilitate our understanding of these receptors' role in asthma. We aimed to investigate the localization and interactions of CysLTRs using a mouse model of asthma. BALB/c mice were administered ovalbumin
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Xenobiotica; the fate of foreign compounds in biological systems, 51(3), 251-261 (2020-10-21)
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