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SML0101

Sigma-Aldrich

孟鲁司特 钠 水合物

≥98% (HPLC)

别名:

1-[[[(1R)-1-[3-[(1E)-2-（7-氯-2-喹啉基）乙烯基] 苯基]-3-[2-（1-羟基-1-甲基乙基）苯基] 丙基] 硫代] 甲基] 环丙烷乙酸 钠盐 水合物

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1 G
CN¥1,033.51
5 G
CN¥4,129.87
25 G
CN¥16,459.57

CN¥1,033.51

预计发货时间May 22, 2025详情

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1 G
CN¥1,033.51
5 G
CN¥4,129.87
25 G
CN¥16,459.57

About This Item

经验公式（希尔记法）:
C35H35ClNO3S·Na · xH2O
分子量:
608.17 (anhydrous basis)
MDL编号:
MFCD20527317
UNSPSC代码:
12352200
PubChem化学物质编号:
329825159
NACRES:
NA.77

CN¥1,033.51

预计发货时间May 22, 2025详情

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方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D +90 to +106° in methanol (c=1)

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥8 mg/mL at 60 °C

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

储存温度

2-8°C

SMILES字符串

O.[Na+].CC(C)(O)c1ccccc1CC[C@@H](SCC2(CC2)CC([O-])=O)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3

InChI

1S/C35H36ClNO3S.Na.H2O/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29;;/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39);;1H2/q;+1;/p-1/b15-10+;;/t32-;;/m1../s1

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product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

product line

Novabiochem®

Quality Level

200

Quality Level

400

Quality Level

400

Quality Level

200

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

peptide synthesis

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

2-30°C

form

beads

form

beads

form

beads

form

beads

应用

孟鲁司特钠水合物已被用作阳性对照药物，用于研究Gumiganghwal-tang水提取物（GGTA）对气道炎症和肺纤维化的保护作用。[1]

生化/生理作用

孟鲁司特钠水合物是一种白三烯受体拮抗剂（LTRA），用于维持哮喘的治疗和缓解季节性过敏症状。它是亚型特异性CysLT1受体拮抗剂。
孟鲁司特钠水合物是亚型特异性 CysLT1 受体拮抗剂；平喘；抗过敏

特点和优势

《受体分类和信号转导》手册的 GABAC受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处了解更多特色 ADME 毒性产品。可访问sigma.com/discover-bsm了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000245579
    0000245579
    0000174951
    0000174950
    0000146572

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    在文件库中查找您最近购买产品的文档。

    访问文档库

    Hoang Kim Tu Trinh et al.
    Prostaglandins, leukotrienes, and essential fatty acids, 141, 17-23 (2019-01-22)
    Identification of the characterization of cysteinyl leukotrienes receptor (CysLTRs) could facilitate our understanding of these receptors' role in asthma. We aimed to investigate the localization and interactions of CysLTRs using a mouse model of asthma. BALB/c mice were administered ovalbumin
    Aqueous extract of gumiganghwal-tang, a traditional herbal medicine, reduces pulmonary fibrosis by transforming growth Factor beta1/Smad signaling pathway in murine model of chronic Asthma
    Jeon WY, et al.
    Testing, 11(10), e0164833-e0164833 (2016)
    Elisa Viciani et al.
    Scientific reports, 6, 20609-20609 (2016-02-11)
    The involvement of pathogenic bacteria in obstructive sleep apnoea syndrome (OSAS) has yet to be elucidated. We investigated the possible role of group A streptococcus (GAS) in OSAS pathogenesis. In 40 tonsillectomized patients affected by OSAS and 80 healthy controls
    Rajesh Chavan et al.
    Xenobiotica; the fate of foreign compounds in biological systems, 51(3), 251-261 (2020-10-21)
    Nafithromycin is a next generation lactone ketolide antibiotic slated to enter phase III clinical development in India for the treatment of CABP as a shorter 800 mg-OD X3 day therapeutic regimen. Nafithromycin exhibits potent activity against MDR Streptococcus pneumoniae including erythromycin and
    Michela Illiano et al.
    Frontiers in oncology, 10, 799-799 (2020-06-26)
    Acute myeloid leukemia (AML) is a progressive hematopoietic-derived cancer arising from stepwise genetic mutations of the myeloid lineage. cAMP response element-binding protein (CREB) is a nuclear transcription factor, which plays a key role in the multistep process of leukemogenesis, thus
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