SML0087
MEGX
≥95% (HPLC)
别名:
MGEX, Monoethylglycinexylidide, N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide, Norlidocaine
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关于此项目
经验公式（希尔记法）:
C12H18N2O
化学文摘社编号:
分子量:
206.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
WRMRXPASUROZGT-UHFFFAOYSA-N
SMILES string
CC1=C(NC(CNCC)=O)C(C)=CC=C1
InChI
1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
MEGX has been used in an approach to improve the yield of N-dealkylated lidocaine.
Biochem/physiol Actions
Lidocaine metabolite
MEGX is generated by hepatic cytochrome P-450 system upon oxidative de-ethylation. Measurement of MEGX by immunoassay contributes to liver function test. MEGX possesses antiarrhythmic action and therefore extends lidocaine effect.
Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Optimization of reaction parameters for the electrochemical oxidation of lidocaine with a Design of Experiments approach
Gul T, et al.
Electrochimica Acta, 171, 23-28 (2015)
K Rolsted et al.
Skin pharmacology and physiology, 22(3), 124-127 (2009-01-13)
Little is known about the metabolising capacity of the human skin in relation to topically applied drugs and formulations. We chose lidocaine as a model compound since the metabolic pathways are well known from studies concerning hepatic metabolism following systemic
Ying Wang et al.
Drug design, development and therapy, 14, 1739-1747 (2020-05-23)
Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug-drug interactions. Given statins have the possibility of combination with lidocaine in the clinic, we established in vitro models to assess the
Georgette Oni et al.
Aesthetic surgery journal, 32(4), 495-503 (2012-03-29)
Topical anesthetics are commonly applied for a variety of indications. Several lidocaine-containing topical anesthetics are available for purchase over the counter (OTC). Recently, the authors' group has shown that there is great interindividual discrepancy in the manner in which lidocaine
D Venkatachalam et al.
New Zealand veterinary journal, 67(5), 228-233 (2019-04-30)
To investigate the analgesic efficacy of articaine hydrochloride for antler removal in red deer (Cervus elaphus) following S/C administration as a ring block, and to quantify the residue concentrations of articaine compared to lignocaine in the harvested antlers. Articaine hydrochloride
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