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SML0067

IOX1

Name: IOX1
Brand: SIGMA
Price: 12361.19 CNY

≥97% (HPLC)

别名:

5-羧基-8-羟基喹啉, 8-羟基-5-喹啉羧酸

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5 PKG

CN¥12,361.19

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5 PKG

CN¥12,361.19

About This Item

经验公式（希尔记法）:

C₁₀H₇NO₃

CAS号:

5852-78-8

分子量:

189.17

MDL编号:

MFCD18417145

UNSPSC代码:

51111800

PubChem化学物质编号:

329825131

NACRES:

NA.77

CN¥12,361.19

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此商品	H5147	SAB4200797	H1775
SAB4200714 Anti-Heat Shock Protein 70 (HSP70) antibody, Mouse monoclonal	H5147 Monoclonal Anti-Heat Shock Protein 70 antibody produced in mouse	$Anti-HSP70 antibody produced in rabbit IgG fraction of antiserum$ SAB4200797 Anti-HSP70 antibody produced in rabbit	H1775 Monoclonal Anti-Heat Shock Protein 90 antibody produced in mouse
species reactivity plant, bovine, rabbit, chicken, human, fish, insect, monkey, dog, rat, sea urchin, mouse	species reactivity bovine, chicken, guinea pig, plant, Drosophila, rat, human, nematode, rabbit, hamster	species reactivity chicken, rat, canine, human, monkey, mouse, bovine	species reactivity wheat germ, chicken, Sf9 cell line, rabbit, rat, human, mouse, Achlya
antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form IgG fraction of antiserum	antibody form ascites fluid
clone BRM-22, monoclonal	clone BRM-22, monoclonal	clone polyclonal	clone AC-16, monoclonal
mol wt antigen ~70 kDa	mol wt antigen 70 kDa	mol wt ~70 kDa	mol wt antigen 88 kDa
isotype IgG1	isotype IgG1	isotype -	isotype IgG2b

应用

IOX1已用于：

消除潜伏病毒的病毒潜伏期，以使病毒感染对抗病毒治疗敏感。[1]
在组蛋白赖氨酸脱甲基酶4A（KDM4A）抑制中，作为减少缺氧诱导因子信号传导的独特策略。[2]
恢复癌基因诱导的野生型小鼠胚胎成纤维细胞衰老。[3]

生化/生理作用

IOX1的IC50值为200nM。[4]IOX1可能通过下调α-球蛋白来治疗β-地中海贫血。[5]

IOX1（5-羧基-8-羟基喹啉）是2-氧戊二酸（2OG）加氧酶（包括Jumonji C域（JmjC）脱甲基酶）的广谱抑制剂。它可用于研究组蛋白去甲基化和低氧感测，并导致2OG加氧酶上活性位点铁的易位。有关表征的完整详细信息，请访问结构基因组学联盟（SGC）网站上的IOX1探针摘要。

想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc

广谱2-氧戊二酸（2OG）加氧酶抑制剂。

特点和优势

IOX1是一种表观遗传化学探针，是我们与结构基因组学协会（SGC）的合作产品。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。

该化合物是基因调控研究推荐产品。点击此处，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

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Not applicable

历史批次信息供参考:

分析证书(COA)

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Selective silencing of alpha-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of beta-thalassemia

Mettananda S, et al.

Haematologica, 102(3), e80-e84 (2017)

A scintillation proximity assay for histone demethylases.

Wenyu Yu et al.

Analytical biochemistry, 463, 54-60 (2014-07-11)

Covalent modifications, such as methylation and demethylation of lysine residues in histones, play important roles in chromatin dynamics and the regulation of gene expression. The lysine demethylases (KDMs) catalyze the demethylation of lysine residues on histone tails and are associated

Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma

Yu Y, et al.

Cancer Cell, 33(2), 322-336 (2018)

IOX1 protects from TGF-β induced fibrosis in LX-2 cells via the regulation of extracellular matrix protein expression.

Tian Tian et al.

Experimental and therapeutic medicine, 21(3), 180-180 (2021-01-26)

The aim of the present study was to investigate the effect of the histone H3K9 demethylase inhibitor, IOX1, on the mechanism of hepatic fibrosis in TGF-β-induced human hepatic stellate LX-2 cells. Cellular proliferation, apoptosis, histone H3K9 dimethylation (H3K9me2), protein expression

Acetylation of intragenic histones on HPV16 correlates with enhanced HPV16 gene expression

Johansson C, et al.

Virology, 482(3), 244-259 (2015)

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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IOX1

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