所有图片(2)
About This Item
经验公式（希尔记法）:
C10H7NO3
CAS号:
分子量:
189.17
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
检测方案
≥97% (HPLC)
形式
powder
颜色
white to brown
溶解性
DMSO: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC(=O)c1ccc(O)c2ncccc12
InChI
1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChI key
JGRPKOGHYBAVMW-UHFFFAOYSA-N
相关类别
应用
IOX1已用于：
- 消除潜伏病毒的病毒潜伏期，以使病毒感染对抗病毒治疗敏感。
- 在组蛋白赖氨酸脱甲基酶4A（KDM4A）抑制中，作为减少缺氧诱导因子信号传导的独特策略。
- 恢复癌基因诱导的野生型小鼠胚胎成纤维细胞衰老。
生化/生理作用
IOX1的IC50值为200nM。IOX1可能通过下调α-球蛋白来治疗β-地中海贫血。
IOX1（5-羧基-8-羟基喹啉）是2-氧戊二酸（2OG）加氧酶（包括Jumonji C域（JmjC）脱甲基酶）的广谱抑制剂。它可用于研究组蛋白去甲基化和低氧感测，并导致2OG加氧酶上活性位点铁的易位。有关表征的完整详细信息，请访问结构基因组学联盟（SGC）网站上的IOX1探针摘要。
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
想要了解用于表观遗传靶标的其他 SGC 化学探针，请访问 sigma.com/sgc
特点和优势
IOX1是一种表观遗传化学探针，是我们与结构基因组学协会（SGC）的合作产品。想要了解更多信息并查看其他SGC表观遗传探针，请访问sigma.com/SGC。
该化合物是基因调控研究推荐产品。点击此处 ，查看更多基因调控精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
相关产品
产品编号
说明
价格
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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