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SML0065

Sigma-Aldrich

Tubacin

≥98% (HPLC)

别名:

N1-[4-[(2R,4R,6S)-4-[[（4,5-二苯基-2-恶唑基）硫代] 甲基]-6-[4-（羟甲基）苯基]-1,3-二恶烷-2-基] 苯基]-N8-羟基-辛二酰胺

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About This Item

经验公式（希尔记法）:
C41H43N3O7S
CAS号:
537049-40-4
分子量:
721.86
MDL编号:
MFCD18452824
UNSPSC代码:
12352200
PubChem化学物质编号:
329825129
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

OCC1=CC=C(C=C1)[C@@H]2C[C@H](CSC3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)O[C@H](C6=CC=C(NC(CCCCCCC(NO)=O)=O)C=C6)O2

InChI

1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1

InChI key

BHUZLJOUHMBZQY-YXQOSMAKSA-N

应用

Tubacin被用于研究 HDAC6 在膀胱癌细胞迁移和侵袭中的作用。

生化/生理作用

Tubacin 可触发活性氧的释放并介导不依赖 caspase-3 的 eb 病毒 (EBV) 阳性 Burkitt 淋巴瘤细胞凋亡。它可抑制急性淋巴细胞白血病 (ALL) 细胞的增殖，增强ALL细胞化疗效果。Tubacin 可预防大鼠中由于 Srpx2 表达降低引起的癫痫活动和神经元迁移缺陷。
Tubacin 是组蛋白去乙酰化酶 6 (HDAC6) 的选择性抑制剂，HDAC6 是一种主要参与许多细胞过程的细胞质 II 类组蛋白去乙酰化酶，包括错误折叠蛋白的降解、细胞迁移和细胞间相互作用。Tubacin 选择性抑制 HDAC6 介导的 α-微管蛋白去乙酰化。
选择性组蛋白去乙酰化酶 6 (HDAC6) 抑制剂

特点和优势

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000156780
0000156781
0000156780
0000128586

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Junichi Kawada et al.
The Journal of biological chemistry, 284(25), 17102-17109 (2009-04-24)
Tubacin is a small molecule inhibitor of histone deacetylase 6 and blocks aggresome activity. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were generally killed by lower doses of tubacin than EBV-transformed lymphoblastoid cells (LCLs) or EBV-negative BL
Harald Witte et al.
The Journal of cell biology, 180(3), 619-632 (2008-02-13)
Axon formation is the initial step in establishing neuronal polarity. We examine here the role of microtubule dynamics in neuronal polarization using hippocampal neurons in culture. We see increased microtubule stability along the shaft in a single neurite before axon
Laura Melchionda et al.
Orphanet journal of rare diseases, 8, 66-66 (2013-05-03)
We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient
Manal Salmi et al.
Brain : a journal of neurology, 136(Pt 8), 2457-2473 (2013-07-09)
Altered development of the human cerebral cortex can cause severe malformations with often intractable focal epileptic seizures and may participate in common pathologies, notably epilepsy. This raises important conceptual and therapeutic issues. Two missense mutations in the sushi repeat-containing protein
Grace I Aldana-Masangkay et al.
Leukemia & lymphoma, 52(8), 1544-1555 (2011-06-28)
Over the past decade, histone deacetylase inhibitors have increasingly been used to treat various malignancies. Tubacin (tubulin acetylation inducer) is a small molecule that inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin. We observed a higher antiproliferative effect
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