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SML0063

Sigma-Aldrich

Q-VD-OPh 水合物

≥95% (HPLC)

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别名:
5-(2,6-二氟苯氧基)-3-[[3-甲基-1-氧代-2-[(2-喹啉基羰基)氨基]丁基]氨基]-4-氧代-戊酸 水合物
经验公式（希尔记法）:
C26H25F2N3O6 · xH2O
CAS号:
1435786-01-8
分子量:
513.49 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
329825128
NACRES:
NA.77

检测方案

≥95% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to light brown

溶解性

DMSO: ≥14 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

O=C(NC(C(C)C)C(NC(C(COC1=C(F)C=CC=C1F)=O)CC(O)=O)=O)C2=NC3=CC=CC=C3C=C2.[H]O[H]

InChI

1S/C26H25F2N3O6.H2O/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28;/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34);1H2/t20-,23-;/m0./s1

InChI key

ONOTWLLTFZMERH-WCRWPNQISA-N

应用

Q-VD-OPh水合物已用于：
  • 作为泛胱天蛋白酶抑制剂防止细胞(UCC)死亡
  • 诱发UC细胞中典型的胱天蛋白酶依赖细胞凋亡
  • 抑制胱天蛋白酶3和多聚ADP-核糖聚合酶1(PARP-1)
  • 研究人表皮细胞中EspZ效应蛋白抗细胞凋亡和坏死的保护作用

生化/生理作用

Q-VD-OPh是一种有效的泛半胱天冬酶抑制剂，可保护细胞免于半胱天冬酶依赖性细胞凋亡。 Q-VD-OPh的水稳定性、细胞渗透性和功效优于基于FMK的半胱天冬酶抑制剂，且单用无细胞毒性。

特点和优势

该化合物在受体分类和信号转导手册的 半胱天冬酶 页面上有详细描述。如需浏览其他手册页面，请点击此处。
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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The diarrheagenic pathogen enteropathogenic Escherichia coli (EPEC) limits the death of infected enterocytes early in infection. A number of bacterial molecules and host signaling pathways contribute to the enhanced survival of EPEC-infected host cells. EspZ, a type III secreted effector
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