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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
DMSO: ≥13 mg/mL
储存温度
2-8°C
SMILES字符串
CCCCCCC1CCC\C1=N/NC(N)=S
InChI
1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
InChI key
OWGUSBISUVLUJF-SDNWHVSQSA-N
应用
BLT-1可用于研究在胆固醇流入和流出中起作用的细胞信号通路。
BLT-1（阻断脂质转运-1）已被用作SR-BI（清道夫受体，B类，I型）介导的脂质转移的抑制剂，以确定miR-223-3p是否从多形核中性粒细胞（PMN）输出高密度脂蛋白（HDL）依赖于SR-BI介导的脂质通量。它也被用作SR-BI抑制剂，通过SR-B1研究HDL对单核细胞系中骨钙素（OCN）表达的影响。
生化/生理作用
阻断脂质转运-1（BLT-1）是SR-BI（清道夫受体，B类，I型）介导的脂质转移的特异性抑制剂。该化合物抑制HDL胆固醇醚的细胞选择性脂质摄取和细胞胆固醇向HDL的流出。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ivana Halova et al.
Frontiers in immunology, 3, 119-119 (2012-06-02)
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react
High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes
Maddaloni E, et al.
Cardiovascular Diabetology, 16(1), 1-11 (2017)
Ceren Emre et al.
Brain pathology (Zurich, Switzerland), 30(3), 614-640 (2020-01-09)
Neuroinflammation is a key element of AD pathology and conceivably a result of a disturbed resolution. Resolution of inflammation is an active process which is strictly orchestrated following the acute inflammatory response after removal of the inflammatory stimuli. Acute inflammation
Fumiyuki Sasaki et al.
PloS one, 12(9), e0185133-e0185133 (2017-09-19)
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available. In this
Claudia S Bitencourt et al.
Journal of cellular and molecular medicine, 17(12), 1554-1565 (2014-01-01)
Insufficient oxygen delivery to organs leads to tissue dysfunction and cell death. Reperfusion, although vital to organ survival, initiates an inflammatory response that may both aggravate local tissue injury and elicit remote organ damage. Polymorphonuclear neutrophil (PMN) trafficking to remote
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