所有图片(1)
别名:
(6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate
经验公式（希尔记法）:
C18H23N9O4S3 · 2HCl · xH2O
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to tan
溶解性
H2O: ≥22 M
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
InChI
1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1
InChI key
BWRRTAXZCKVRON-DGPOFWGLSA-N
一般描述
Chemical structure: ß-lactam
应用
Cefotiam dihydrochloride hydrate is used as broad-spectrum antibiotic.
生化/生理作用
Cefotiam is a second generation cephalosporin antibiotic which has been used as a prophylatic antibiotic for MRSA.
Cefotiam, a derivative of cephalosporin, exhibits broad-spectrum anti-bacterial activity. It inhibits the cross-linking stage of peptidoglycan and blocks the synthesis of bacterial cell wall. It is resistant to β-lactamases.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
J R Lentino et al.
Antimicrobial agents and chemotherapy, 25(6), 778-780 (1984-06-01)
Cefotiam was evaluated by a comparative open-label randomized trial with cephalothin in the therapy of skin and soft tissue infections in 39 patients. The most common organism isolated was Staphylococcus aureus (78%). We established evidence of primary infection with gram-negative
Rainer Müller et al.
Arzneimittel-Forschung, 53(2), 126-132 (2003-03-20)
The efficacy of the perioperative short-term prophylaxis with cefotiam (CAS 66309-69-1) and cefuroxime axetil (CAS 64544-07-6) was analysed by the assessment of the pharmacological kinetics in the serum and the tonsil tissue in 50 patients with recurrent tonsillitis. Twenty-four patients
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