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质量水平
检测方案
≥94% (HPLC)
形式
powder
旋光性
[α]/D +95 to +115°, c = 1 in methanol
颜色
white to tan
溶解性
H2O: ≥5 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c3O[C@@H]([C@@H](C(=O)O[C@H](Cc4ccc(O)c(O)c4)C(O)=O)c23)c5ccc(O)c(O)c5
InChI
1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31+,32-/m1/s1
InChI key
SNKFFCBZYFGCQN-VWUOOIFGSA-N
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应用
丹酚酸 B 也已被用于处理原代神经元细胞,以测试其对细胞活力的影响。
丹酚酸B(Sal B)已用于通过硫黄素T(ThT)荧光法测定丹酚酸B对α-突触核蛋白聚集动力学的抑制作用。它还用作参考化合物,用于通过指纹图谱分析确认myelophil(黄芪丹参混合物)的可重复性。
生化/生理作用
丹酚酸 B 是一种具有细胞保护作用的抗氧化剂和自由基清除剂,广泛用于治疗缺血性心脏病和阿尔茨海默病。已提出了几种作用机制,包括 EGFR、PDGF 和 MMP-9 抑制以及 TGF-β1/Smads 和 NF-κB 信号通路抑制。丹酚酸 B 作为活性氧的清除剂,减少白细胞对内皮细胞的粘附,抑制基质金属蛋白酶和炎症。它具有心脏保护作用,因为它能减少受损心脏组织中的脂质过氧化,并减少乳酸脱氢酶的漏出。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Translational neurodegeneration, 8(1), 18-18 (2019)
Plants (Basel, Switzerland), 10(6) (2021-07-03)
Arthritis is a common condition that causes pain and inflammation in a joint. Previously, we reported that the mixture extract (ME) from Agrimonia pilosa Ledeb. (AP) and Salvia miltiorrhiza Bunge (SM) could ameliorate gout arthritis. In the present study, we
Journal of pharmaceutical and biomedical analysis, 43(4), 1249-1255 (2006-11-23)
The degradation of lithospermic acid B (LAB) was investigated as a function of buffer concentration, pH and temperature. Stability tests were performed using a stability-indicating high-performance liquid chromatography (HPLC) with UV-vis detection. The degradation followed pseudo-first-order kinetics under all experimental
Journal of pharmaceutical and biomedical analysis, 43(2), 435-439 (2006-09-05)
The hydrolytic kinetics of lithospermic acid B (LAB) extracted from the roots of Salvia miltiorrhiza (Chinese herb: danshen) was investigated by using reversed-phase high-performance liquid chromatography (HPLC) with UV-vis detection. The influences of initial drug concentration, pH and temperature on
Ultrasonics sonochemistry, 19(4), 719-724 (2012-01-24)
We studied the effect of ultrasonication extraction technology combined with ammonium sulfate/ethanol aqueous two-phase system (ATPS) for the separation of lithospermic acid B (LAB) from Salvia miltiorrhiza Bunge. According to the literature and preliminary studies, ammonium sulfate concentration, ethanol concentration
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