所有图片(1)
About This Item
经验公式（希尔记法）:
C26H22O10 · xH2O
CAS号:
分子量:
494.45 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
方案
≥98% (HPLC)
表单
powder
颜色
yellow
溶解性
H2O: ≥19 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
O.OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2\C=C\c3ccc(O)c(O)c3
InChI
1S/C26H22O10.H2O/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15;/h1-12,23,27-31,33H,13H2,(H,34,35);1H2/b6-1+,10-5+;/t23-;/m1./s1
InChI key
XFUSRNNWIRPEDG-FYLUTCCGSA-N
应用
丹酚酸 A 水合物可用于细胞信号传导研究。
丹酚酸 A 水合物已被用作迷迭香酸衍生物，用于抑制人细胞系中的 DNA 聚合酶 e。
丹酚酸 A 水合物已被用作迷迭香酸衍生物，用于抑制人细胞系中的 DNA 聚合酶 e。
生化/生理作用
丹酚酸 A 作为活性氧的清除剂，减少白细胞对内皮细胞的粘附，抑制基质金属蛋白酶和炎症。它具有心脏保护作用，因为它抑制细胞凋亡，减少受损心脏组织中的脂质过氧化，并减少乳酸脱氢酶的泄漏。
丹酚酸 A 是最初从丹参中分离得到的具有细胞保护作用的抗氧化剂。研究发现它能减弱 PDGF 诱导的肝星状细胞 ROS 的形成，对异丙肾上腺素诱导的大鼠心肌损伤有保护作用。
细胞保护性抗氧化剂
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Huaying Fan et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 508938-508938 (2011-07-27)
Salvianolic acid A (SAA), one of the major active components of Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims to investigate the cardioprotection of SAA
Li Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(19), 2603-2609 (2012-01-17)
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the
Xiao-Juan Lai et al.
Fitoterapia, 82(6), 883-888 (2011-05-18)
Salviae miltiorrhizae is one of the most commonly used herbal plants in the treatment of numerous ailments including cardiovascular diseases for hundreds of years. According to the theory of traditional Chinese herbal medicine, S. miltiorrhizae is always used in combination
Heng-ai Zhang et al.
Biochemical and biophysical research communications, 421(3), 479-483 (2012-04-21)
Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease
Baohong Jiang et al.
PloS one, 8(3), e59621-e59621 (2013-03-28)
Cardiac fibrosis is a deleterious consequence of hypertension which may further advance to heart failure and increased matrix metalloproteinase-9 (MMP-9) contributes to the underlying mechanism. Therefore, new therapeutic strategies to attenuate the effects of MMP-9 are urgently needed. In the
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