所有图片(1)
别名:
N-羟基-4-(2-甲基-1,2,3,4-四氢-吡啶并[4,3-b]吲哚-5-基甲基)苯甲酰胺盐酸盐；N-羟基-4-((2-甲基-3,4-二氢-1H-吡啶并[4,3-b]吲哚-5(2H)- 基)甲基)苯甲酰胺 盐酸盐
经验公式（希尔记法）:
C20H21N3O2·HCl
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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to tan
溶解性
DMSO: ≥10 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl
InChI
1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
InChI key
LJTSJTWIMOGKRJ-UHFFFAOYSA-N
应用
Tubastatin A盐酸盐可用于HDAC6介导的细胞信号传导研究。
生化/生理作用
Tubastatin A是一种选择性很强的HDAC6抑制剂，IC50为4 nM，它对HDAC6的选择性比其他HDAC类高100至1000倍以上。
Tubastatin A能够增加线粒体的总数并恢复DRG神经元中移动线粒体的数量。它能够逆转腓骨肌萎缩症小鼠模型中外周神经元的轴突丧失。 Tubastatin A可以抑制小鼠成肌细胞中α-微管蛋白的去乙酰化。
特点和优势
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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