所有图片(1)
别名:
BB-94；（2R,3S）-N4- 羟基-N1-[（1S）-2-（甲基氨基）-2-氧代-1-（苯甲基）乙基] -2-（2-甲基丙基）-3-[（2-噻吩基硫基基）甲基] 丁二酰胺
经验公式（希尔记法）:
C23H31N3O4S2
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to tan
溶解性
DMSO: ≥15 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc2cccs2)C(=O)NO
InChI
1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1
InChI key
XFILPEOLDIKJHX-QYZOEREBSA-N
应用
巴马司他已在多种研究中被用于抑制基质金属蛋白酶（MMP）的活性。
生化/生理作用
巴马司他是基质金属蛋白酶（MMP）的异羟肟酸类抑制剂。它抑制小鼠模型中肺肿瘤的生长和扩散，乳腺癌再生和人结肠肿瘤的生长和扩散。巴马司他降低 MMP 介导的血管功能障碍和血管壁损伤，并增强牙科粘合剂的密封性能和粘合强度。
巴马司他是一种有效的广谱基质金属蛋白酶（MMP）抑制剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ricardo L Sanz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(3), 518-529 (2017-12-03)
Cell-surface molecules are dynamically regulated at the synapse to assemble and disassemble adhesive contacts that are important for synaptogenesis and for tuning synaptic transmission. Metalloproteinases dynamically regulate cellular behaviors through the processing of cell surface molecules. In the present study
X Wang et al.
Cancer research, 54(17), 4726-4728 (1994-09-01)
Matrix metalloproteinases have been implicated in the growth and spread of metastatic tumors. This role was investigated in an orthotopic transplant model of human colon cancer in nude mice using the matrix metalloproteinase inhibitor BB-94 (batimastat). Fragments of human colon
Joseph D Raffetto et al.
Biochemical pharmacology, 75(2), 346-359 (2007-08-07)
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade various components of the extracellular matrix (ECM). Members of the MMP family include collagenases, gelatinases, stromelysins, matrilysins and membrane-type MMPs. ProMMPs are cleaved into active forms that promote degradation
Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice
Sandri A, et al.
Virulence, 9(1), 1008-1018 (2018)
G W Sledge et al.
Journal of the National Cancer Institute, 87(20), 1546-1550 (1995-10-18)
Matrix metalloproteinases (MMPs) are involved in the invasion and metastasis of human cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes constitute promising targets in the development of anticancer therapies. Batimastat ([(4-N-hydroxyamino)-2R-isobutyl-3S-(thienyl-thiomethyl)succinyl]-L- phenyl-alanine-N-methylamide) is one of a
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