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经验公式(希尔记法):
C24H25FNO4 · Na · xH2O
化学文摘社编号:
分子量:
433.45 (anhydrous basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Fluvastatin 钠 水合物, ≥98% (HPLC)
SMILES string
O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI
1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
InChI key
KKEMYLLTGGQWCE-PMRANXHDSA-M
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥9 mg/mL
originator
Novartis
storage temp.
2-8°C
Quality Level
Application
氟伐地汀钠水合物已被用于:
- 测试其抗丙肝病毒 (HCV) 活性
- 作为胆固醇抑制剂
- 研究其对β-葡聚糖诱导的单核细胞免疫驯化的作用
氟伐地汀钠水合物已被用于:
- 考察其对β -葡聚糖诱导的免疫驯化的作用
- 研究斯达汀对解偶联蛋白 (UCP1)+细胞数目的影响
- 确定其对星形胶质细胞胰岛素降解酶 (IDE) 分泌的影响
- 治疗并研究其对脐静脉内皮细胞 (HUVEC) 的体外作用
Biochem/physiol Actions
氟伐他汀是羟甲基戊二酰辅酶A(HMG-CoA)还原酶的一种竞争性抑制剂,该酶可催化HMG-CoA转化为甲羟戊酸,而这是胆固醇生物合成中的限速步骤。氟伐他汀可抗血脂,能用于降低血浆胆固醇的水平并预防心血管疾病。
氟伐地汀具有抗真菌活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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