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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to tan
溶解性
H2O: ≥9 mg/mL
创始人
Novartis
储存温度
2-8°C
SMILES字符串
O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI
1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
InChI key
KKEMYLLTGGQWCE-PMRANXHDSA-M
应用
氟伐地汀钠水合物已被用于:
- 测试其抗丙肝病毒 (HCV) 活性
- 作为胆固醇抑制剂
- 研究其对β-葡聚糖诱导的单核细胞免疫驯化的作用
氟伐地汀钠水合物已被用于:
- 考察其对β -葡聚糖诱导的免疫驯化的作用
- 研究斯达汀对解偶联蛋白 (UCP1)+细胞数目的影响
- 确定其对星形胶质细胞胰岛素降解酶 (IDE) 分泌的影响
- 治疗并研究其对脐静脉内皮细胞 (HUVEC) 的体外作用
生化/生理作用
氟伐他汀是羟甲基戊二酰辅酶A(HMG-CoA)还原酶的一种竞争性抑制剂,该酶可催化HMG-CoA转化为甲羟戊酸,而这是胆固醇生物合成中的限速步骤。氟伐他汀可抗血脂,能用于降低血浆胆固醇的水平并预防心血管疾病。
氟伐地汀具有抗真菌活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
The Journal of pharmacology and experimental therapeutics, 338(1), 62-69 (2011-04-07)
HMG-CoA reductase inhibitor statins are used for the treatment of hypercholesterolemia. However, statins have adverse effects on skeletal muscles with unknown mechanism. We have reported previously that fluvastatin induced vacuolation and cell death in rat skeletal myofibers by depleting geranylgeranylpyrophosphate
Avasimibe: a novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles
Antiviral Research, 148, 5-14 (2017)
Inhibition of mevalonate pathway prevents adipocyte browning in mice and men by affecting protein prenylation
Cell Metabolism, 29(4), 901-916 (2019)
Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
Mol. Neurodegener., 10(1), 56-56 (2015)
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-beta in iPSC-Derived Alzheimer?s Disease Neurons
Cell Stem Cell, 24(3), 363-375 (2019)
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