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Merck
CN

SML0037

Ceftibuten hydrate

90-102% anhydrous basis (HPLC)

别名:

(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-buten-1-yl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate

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关于此项目

经验公式（希尔记法）:
C15H14N4O6S2 · xH2O
化学文摘社编号:
97519-39-6
分子量:
410.42 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
329825107
UNSPSC Code:
51284115
MDL number:
MFCD20488049

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产品名称

Ceftibuten hydrate, 90-102% anhydrous basis (HPLC)

InChI

1S/C15H14N4O6S2.H2O/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19;/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25);1H2/b6-1-;/t10-,13-;/m1./s1

SMILES string

O.Nc1nc(cs1)\C(=C\CC(O)=O)C(=O)N[C@H]2[C@H]3SCC=C(N3C2=O)C(O)=O

InChI key

JMLVKZRNRBPPDZ-TXOBIQCCSA-N

assay

90-102% anhydrous basis (HPLC)

form

crystalline powder

storage condition

desiccated

color

white to pale yellow

solubility

DMSO: ≥50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Ceftibuten is a β-lactam antibiotic with antibacterial activity. It is effective for mild-to-moderate respiratory infections. It displays high stability against extended-spectrum β-lactamases producing bacteria.
Ceftibuten is a third generation cephalosporin antibiotic
Third generation cephalosporin antibiotic

General description

Chemical structure: ß-lactam

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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分析证书(COA)

Lot/Batch Number
0000457077
0000457078
0000457078
0000457077
0000452432

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Shirou Itagaki et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 77-82 (2004-08-19)
(-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine (nateglinide) is a novel oral hypoglycemic agent possessing a carboxyl group and a peptide-type bond in its structure. Although nateglinide quickly reaches the maximal serum concentration after oral administration, nateglinide itself is not transported by PepT1 or MCT1. The
Miyako Okamura et al.
Pharmaceutical research, 20(9), 1389-1393 (2003-10-22)
The aim of this study was to examine the effects of zinc on the intestinal peptide transporters (PEPT1 and basolateral peptide transporter) and to elucidate the mechanism of the interactions. Caco-2 cells were pretreated with zinc, and the uptake studies
Branka Bedenic et al.
Chemotherapy, 52(6), 293-297 (2006-09-30)
In this investigation, the urine samples obtained in a single oral-dose pharmacokinetic study were examined for their bactericidal activity against a range of relevant urinary tract pathogens. Six healthy volunteers received a single oral dose of ten oral antibiotics available
Masaki Kobayashi et al.
Biochimica et biophysica acta, 1715(1), 19-24 (2005-08-10)
Nateglinide, a novel oral hypoglycemic agent, possesses a carbonyl group and a peptide-type bond in its structure. We previously reported that nateglinide transport occurs via a single system that may be identical to the ceftibuten/H(+) cotransport system by the rat
Goran Palcevski et al.
Pharmacoepidemiology and drug safety, 13(3), 181-185 (2004-04-10)
In this study, we evaluated antibiotic utilisation pattern at two paediatric clinics in different European (transitional) countries: Croatia (Rijeka) and Russia (Smolensk). Antibiotic utilisation during the year 2000 was observed using the ATC/defined daily doses (DDD) methodology (ATC code-J01). Drug-usage
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