SML0037
Ceftibuten hydrate
90-102% anhydrous basis (HPLC)
别名:
(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-4-carboxy-1-oxo-2-buten-1-yl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate
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关于此项目
经验公式（希尔记法）:
C15H14N4O6S2 · xH2O
化学文摘社编号:
分子量:
410.42 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51284115
MDL number:
InChI
1S/C15H14N4O6S2.H2O/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19;/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25);1H2/b6-1-;/t10-,13-;/m1./s1
SMILES string
O.Nc1nc(cs1)\C(=C\CC(O)=O)C(=O)N[C@H]2[C@H]3SCC=C(N3C2=O)C(O)=O
InChI key
JMLVKZRNRBPPDZ-TXOBIQCCSA-N
assay
90-102% anhydrous basis (HPLC)
form
crystalline powder
storage condition
desiccated
color
white to pale yellow
solubility
DMSO: ≥50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
General description
Chemical structure: β-lactam
Biochem/physiol Actions
Ceftibuten is a β-lactam antibiotic with antibacterial activity. It is effective for mild-to-moderate respiratory infections. It displays high stability against extended-spectrum β-lactamases producing bacteria.
Ceftibuten is a third generation cephalosporin antibiotic
Third generation cephalosporin antibiotic
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Ceftibuten
Wiseman LR and Balfour JA
Drugs, 47(5), 784-808 (1994)
Goran Palcevski et al.
Pharmacoepidemiology and drug safety, 13(3), 181-185 (2004-04-10)
In this study, we evaluated antibiotic utilisation pattern at two paediatric clinics in different European (transitional) countries: Croatia (Rijeka) and Russia (Smolensk). Antibiotic utilisation during the year 2000 was observed using the ATC/defined daily doses (DDD) methodology (ATC code-J01). Drug-usage
Yoshitaka Saito et al.
Biochemical and biophysical research communications, 340(3), 879-886 (2006-01-13)
(-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (nateglinide) is a novel oral hypoglycemic agent possessing a peptide-type bond and a carboxyl group in its structure. Recently, we have shown that nateglinide transport occurs via the ceftibuten/H+ cotransport system, which is distinct from PepT1, and that the
beta-Lactam antibiotics
Infectious Diseases, 1340-1354 (2010)
A case of selective IgE-mediated hypersensitivity to ceftibuten.
M Atanasković-Marković et al.
Allergy, 60(11), 1454-1454 (2005-10-04)
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