质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to tan
溶解性
DMSO: ≥18 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
InChI
1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
InChI key
DERJYEZSLHIUKF-UHFFFAOYSA-N
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应用
Procarbazine hydrochloride has been used to study its physicochemical property.
Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.
生化/生理作用
Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.
Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkin′s disease.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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