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SML0031

Sigma-Aldrich

DBeQ

≥98% (HPLC)

别名:

JRF 12, N2，N4-二苄基喹唑啉-2,4-二胺

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About This Item

经验公式（希尔记法）:
C22H20N4
CAS号:
177355-84-9
分子量:
340.42
MDL编号:
MFCD03691820
UNSPSC代码:
12352200
PubChem化学物质编号:
329825101
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: ≥20 mg/mL

储存温度

room temp

SMILES字符串

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChI key

QAIMUUJJAJBPCL-UHFFFAOYSA-N

应用

用DBeQ处理HeLa细胞，并通过活细胞成像对该处理对细胞 体内 泛素化和蛋白质脱位的影响进行了研究。

生化/生理作用

DBeQ是ATP酶p97的有效和特异性抑制剂，ATP酶是泛素-融合降解（UFD）途径的组成部分。DBeQ可抑制泛素化蛋白质的降解、内质网相关的降解途径、以及自噬体成熟。该化合物还可有效抑制细胞增殖并诱导胱天蛋白酶3/7的活性和细胞凋亡。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000240745
0000240744
0000237513
0000237513
0000240745

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of Product SML0031, DBeQ?

    Product SML0031, DBeQ, is soluble to 100 mM with DMSO and to 20 mM with ethanol.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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ACS chemical biology, 15(1), 243-253 (2019-12-04)
VCP/p97 belongs to the AAA+ ATPase family and has an essential role in several cellular processes ranging from cell division to protein homeostasis. Compounds targeting p97 inhibit the main ATPase domain and cause cell death. Here, using PNA-encoded chemical libraries
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