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Merck
CN
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安全信息

SML0028

Sigma-Aldrich

FR-171113

≥98% (HPLC)

别名:

FR-171113, 2-[3-(4-chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid, methyl ester

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About This Item

经验公式（希尔记法）:
C19H11Cl3N2O4S
CAS号:
173904-50-2
分子量:
469.73
UNSPSC代码:
12352200
PubChem化学物质编号:
329825099
NACRES:
NA.25

方案

≥98% (HPLC)

表单

powder

溶解性

DMSO: ≥5 mg/mL

储存温度

2-8°C

SMILES字符串

COC(=O)\C=C1\SC(=N\C(=O)c2ccc(Cl)cc2Cl)\N(C1=O)c3ccc(Cl)cc3

InChI

1S/C19H11Cl3N2O4S/c1-28-16(25)9-15-18(27)24(12-5-2-10(20)3-6-12)19(29-15)23-17(26)13-7-4-11(21)8-14(13)22/h2-9H,1H3/b15-9+,23-19+

InChI key

SDGLYCKTPKZBGI-MSDDKZNZSA-N

生化/生理作用

FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.

象形图

Environment
GHS09

警示用语：

Warning

危险声明

H410

预防措施声明

P273 - P501

危险分类

Aquatic Acute 1 - Aquatic Chronic 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
051M4618V
0000084903

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Carl J May et al.
American journal of physiology. Renal physiology, 317(4), F913-F921 (2019-07-25)
The specific pathogenesis of idiopathic nephrotic syndrome (NS) is poorly understood, and the role of immune mediators remains contentious. However, there is good evidence for the role of a circulating factor, and we recently postulated circulating proteases as candidate factors.

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