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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
red to brown
溶解性
DMSO: >25 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O
InChI
1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
InChI key
HEKJYZZSCQBJGB-UNOMPAQXSA-N
应用
采用 C646 研究 p300 在慢性压迫性损伤大鼠慢性神经病理性疼痛中的作用。
生化/生理作用
C646 是 p300 和 CBP (p300/CBP) 组蛋白乙酰转移酶的强效、细胞渗透性和选择性抑制剂。C646 抑制 p300/CBP 影响多种转录因子如 NF-κ 的活性p53 和 MyoD 与生理学、疾病过程、海马突触可塑性、空间记忆和情境恐惧相关。
C646 是一种强效、竞争性、选择性组蛋白乙酰转移酶 (HAT) p300/CBP 抑制剂。
C646 是一种竞争性组蛋白乙酰转移酶 (HAT) p300/CBP 抑制剂，Ki 为 400 nM，与其他乙酰转移酶相比具有选择性。
特点和优势
该化合物是基因调控研究的特色产品。 点击此处 ，发现更多特色基因调控产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jia Cao et al.
Nature communications, 8(1), 131-131 (2017-07-27)
Diabetes and obesity are characterized by insulin resistance and chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS) caused by increased intestinal permeability during diet-induced obesity promotes insulin resistance in mice. Here, we show that LPS induces endoplasmic reticulum
Liduan Zheng et al.
Scientific reports, 7(1), 8967-8967 (2017-08-23)
Recent evidence shows the emerging roles of promoter-targeting endogenous microRNAs (miRNAs) in regulating gene transcription. However, miRNAs affecting the transcription of matrix metalloproteinase 14 (MMP-14) in gastric cancer remain unknown. Herein, through integrative mining of public datasets, we identified the
Erin M Bowers et al.
Chemistry & biology, 17(5), 471-482 (2010-06-11)
The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported, a potent, selective, and readily available active-site-directed small molecule inhibitor is not yet known. Here
Arunava Bandyopadhaya et al.
Frontiers in microbiology, 8, 1211-1211 (2017-07-18)
Some bacterial quorum sensing (QS) small molecules are important mediators of inter-kingdom signaling and impact host immunity. The QS regulated small volatile molecule 2-aminoacetophenone (2-AA), which has been proposed as a biomarker of
Zhuofeng Ding et al.
Frontiers in neuroscience, 12, 341-341 (2018-06-08)
Peripheral nerve injuries are generally associated with incomplete restoration of motor function. The slow rate of nerve regeneration after injury may account for this. Although many benefits of resveratrol have been shown in the nervous system, it is not clear
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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