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质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
red to brown
溶解性
DMSO: >25 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O
InChI
1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
InChI key
HEKJYZZSCQBJGB-UNOMPAQXSA-N
应用
采用 C646 研究 p300 在慢性压迫性损伤大鼠慢性神经病理性疼痛中的作用。
生化/生理作用
C646 是 p300 和 CBP (p300/CBP) 组蛋白乙酰转移酶的强效、细胞渗透性和选择性抑制剂。C646 抑制 p300/CBP 影响多种转录因子如 NF-κ 的活性p53 和 MyoD 与生理学、疾病过程、海马突触可塑性、空间记忆和情境恐惧相关。
C646 是一种竞争性组蛋白乙酰转移酶 (HAT) p300/CBP 抑制剂,Ki 为 400 nM,与其他乙酰转移酶相比具有选择性。
特点和优势
该化合物是基因调控研究的特色产品。 点击此处 ,发现更多特色基因调控产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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