生物来源
plant
检测方案
≥90% (LC/MS-ELSD)
形式
solid
分子量
308.37
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
InChI
1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
InChI key
QKUFZFLZBUSEHN-CZLJMHDISA-N
一般描述
Inulicin, a sesquiterpene lactone, is a natural bioactive compound commonly sourced from plants like Pentanema britannicum and Inula japonica. Current research indicates that this plant-derived metabolite may possess inhibitory properties, showcasing a range of biological activities, including anti-inflammatory, cardioprotective, antiangiogenic, and anticancer activities.
应用
Inulicin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
生化/生理作用
Inulicin exhibits anticancer properties by inhibiting angiogenesis and lung cancer cell proliferation, potentially through the regulation of VEGFR-Src-FAK signaling. When combined with gemcitabine, it promotes strong apoptosis in lung cancer cells. Additionally, Inulicin shows promise in the treatment of various cardiovascular diseases, including chronic ischemia, by modulating VEGF signaling and angiogenesis. It also serves as a potent inhibitor of LPS-induced inflammatory responses in vascular smooth muscle cells, acting through the blockade of NF-kappaB activity and the suppression of the inflammatory gene COX-2. Furthermore, Inulicin displays potential as a natural skin-lightening agent, reducing melanogenesis by suppressing tyrosinase expression via ERK and Akt signaling pathways.
特点和优势
- Suitable for Biochemical and Biomedical research
- Versatile and adaptable for wide variety of laboratory and research applications
其他说明
For additional information on our range of Biochemicals, please complete this form.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
L F Belova et al.
Farmakologiia i toksikologiia, 44(4), 463-467 (1981-07-01)
Inulicin is a sesquiterpene lactone obtained from Inula Japonica L. (Compositae) possesses a fairly wide spectrum of pharmacological action. In doses from 5 to 60 mg/kg it exerts a certain stimulant action on the central nervous system and smooth muscles
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