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安全信息

SMB01065

Sigma-Aldrich

Neolicuroside

≥85% (LC/MS-ELSD)

别名:

4-O-(beta-D-apiofuranosyl(1-2)-beta-D-glucopyranosyl)isoliquiritigenin, Isoliquiritigenin-4′-O-apiosyl(1→2)glucoside, Isoliquiritin apioside

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About This Item

经验公式（希尔记法）:
C26H30O13
CAS号:
120926-46-7
分子量:
550.51
MDL编号:
MFCD20487832
UNSPSC代码:
12352205
NACRES:
NA.25

生物来源

plant

方案

≥85% (LC/MS-ELSD)

表单

solid

分子量

550.51

溶解性

water: slightly soluble

应用

metabolomics
vitamins, nutraceuticals, and natural products

储存温度

−20°C

SMILES字符串

O1[C@H]([C@@H]([C@@](C1)(O)CO)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc3ccc(cc3)\C=C\C(=O)c4c(cc(cc4)O)O

InChI

1S/C26H30O13/c27-10-19-20(32)21(33)22(39-25-23(34)26(35,11-28)12-36-25)24(38-19)37-15-5-1-13(2-6-15)3-8-17(30)16-7-4-14(29)9-18(16)31/h1-9,19-25,27-29,31-35H,10-12H2/b8-3+/t19-,20-,21+,22-,23+,24-,25+,26-/m1/s1

InChI key

VMMVZVPAYFZNBM-KVFWHIKKSA-N

相关类别

一般描述

Neolicuroside, also known as Isoliquiritin apioside, is a chalcone glycoside structurally related to steroidal saponins. This bioactive plant metabolite is commonly derived from the roots of Glycyrrhiza Sp. plants and has demonstrated anti-inflammatory, anti-tussive, anti-tumor, antigenotoxic(1), anti-diabetic, and antioxidant properties.
Natural product derived from plant source.

应用

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生化/生理作用

Neolicuroside modulates signaling pathways (e.g., MAPK, NF-κB), impacting vital cell processes such as proliferation, differentiation, and apoptosis. Its multitargeted mechanism includes scavenging free radicals, suppressing pro-inflammatory cytokine production, inhibiting matrix metalloproteinase (MMP) activity and hindering cancer cell growth through apoptosis and cell cycle arrest. Furthermore, it also exerts immunomodulatory effects possibly by activating toll-like receptor 4 (TLR4).

特点和优势

  • High quality compound suitable for multiple research applications
  • Compatible with HPLC and mass spectrometry techniques

其他说明

For additional information on our range of Biochemicals, please complete this form.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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访问文档库

Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L
Kaur P, et al.
Toxicology in vitro, 23, 680-686 (2009)

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