推荐产品
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
mp
153.5—154.5 °C
溶解性
chloroform: 20 mg/mL, colorless to light yellow
储存温度
2-8°C
SMILES字符串
O=C(OC)CCC(C)C1CCC2C3CCC4CC(O)CCC4(C)C3C(=O)C(O)C12C
InChI
1S/C25H40O5/c1-14(5-10-20(27)30-4)18-8-9-19-17-7-6-15-13-16(26)11-12-24(15,2)21(17)22(28)23(29)25(18,19)3/h14-19,21,23,26,29H,5-13H2,1-4H3
InChI key
RYGJYUKSMUSEMY-UHFFFAOYSA-N
一般描述
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.
Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.
应用
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.
特点和优势
- Can be used in Metabolomics and Biochemical research
- High-quality compound suitable for multiple research applications
其他说明
For additional information on our range of Biochemicals, please complete this form.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Irina Alimov et al.
The Journal of biological chemistry, 294(10), 3359-3366 (2019-01-17)
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor affecting both host
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门