检测方案
≥98% (GC)
形式
powder
官能团
amide
hydroxyl
脂质类型
sphingolipids
储存温度
−20°C
SMILES字符串
O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO
InChI
1S/C36H73NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h33-34,36,38-39,41H,3-32H2,1-2H3,(H,37,40)/t33-,34+,36-/m0/s1
InChI key
IEZRNEGTKRQRFV-LFBNJJMOSA-N
一般描述
N-硬脂酰基植物鞘氨醇也被称为神经酰胺3。所有神经酰胺都含有鞘氨醇或植物鞘氨醇作为其结构单元，其可通过酰胺键与非羟基、ω羟基或ω羟基酸进行连接。植物鞘氨醇类型的神经酰胺可分为神经酰胺3和7。神经酰胺3含有植物鞘氨醇主链，该主链可通过酰基链与酰基长度为18至24个碳的脂肪酸进行连接。3型神经酰胺包含神经酰胺3和神经酰胺3b。神经酰胺3含有硬脂酸作为侧链。
生化/生理作用
N-硬脂酰植物鞘氨醇是一种细胞间脂质，已发现其可抑制过敏性细胞因子IL-4和TNF-α的表达。
角质层（SC）是表皮的最上层，由七种不同类型的神经酰胺组成。它们存在于SC细胞之间的连续脂质相中，其中还包括胆固醇和游离脂肪酸。皮肤中神经酰胺组成的类型变化被认为决定了SC的生理功能。它们还确定了皮肤的脂质屏障结构，其中神经酰胺3形成了几乎不透水的脂质膜。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Calorimetric and spectroscopic investigations of phytosphingosine ceramide membrane organisation.
Garidel P
Physical Chemistry Chemical Physics, 4(10), 1934-1942 (2002)
Barbora Amélie Čuříková et al.
International journal of pharmaceutics, 534(1-2), 287-296 (2017-10-25)
The activity of transdermal permeation enhancers is usually evaluated in vitro on human or animal skin, but skin samples can be hard to source and highly variable. To provide a more consistent basis for evaluating the activity of permeation enhancers
Barbora Amélie Čuříková-Kindlová et al.
International journal of pharmaceutics, 563, 384-394 (2019-04-09)
Ceramides (Cers) are significant constituents of the stratum corneum (SC), the uppermost skin layer responsible for skin barrier properties. Cers are a heterogeneous group of lipids whose mutual interactions are still unclear. To better understand these interactions, we characterized model
Aneta Vovesná et al.
International journal of pharmaceutics, 596, 120264-120264 (2021-01-25)
Diseases related to a disrupted skin barrier are accompanied by lower levels of ceramides in the stratum corneum (SC) lipid matrix. Delivering ceramides directly into damaged skin is a viable alternative to conventional corticosteroids, but is hindered by their low
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