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生物来源
Allium sativum L.
质量水平
检测方案
≥97% (HPLC)
形式
liquid
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
C=CCSSSCC=C
InChI
1S/C6H10S3/c1-3-5-7-9-8-6-4-2/h3-4H,1-2,5-6H2
InChI key
UBAXRAHSPKWNCX-UHFFFAOYSA-N
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一般描述
二烯丙基三硫醚（DATS）是葱属植物，特别是大蒜中存在的稳定天然生物活性多硫化物之一。
应用
二烯丙基三硫醚（DATS）已被用作外源性硫化氢(（H2S)）供体，用于研究其对尿路上皮癌（UC）细胞体外增殖、细胞凋亡和自噬的作用。
生化/生理作用
对于MetS大鼠（雄性Wistar大鼠）中体外诱导的心肌缺血/再灌注（I/R）损伤，二烯丙基三硫醚具有心脏保护和抗代谢综合征（MetS） 作用。它是一种强效的抗癌剂，通过调节不同癌症相关途径起作用，在体外研究中诱导细胞周期阻滞、细胞凋亡、转移和血管生成。在三阴性乳腺癌（triple-negative breast cancer，TNBC）中，DATS也是一种有效的多药耐药性治疗剂。DATS 及其纳米乳液对于木腐真菌（如云芝 （T. hirsuta）和硫磺菌（ L. sulphureus））有很高的抗真菌活性。 通过激活大鼠脑中的核因子红细胞2相关因子2（Nrf2），它也对心肌缺血/再灌注（I/R）诱导的大脑损伤有保护作用。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Carlos A Silva-Islas et al.
Antioxidants (Basel, Switzerland), 8(9) (2019-09-22)
Stroke is a public health problem due to its high mortality and disability rates; despite these, the pharmacological treatments are limited. Oxidative stress plays an important role in cerebral damage in stroke and the activation of the nuclear factor erythroid
Elisabetta Panza et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 151, 113137-113137 (2022-05-24)
The role of H2S in urothelial carcinoma (UC) is still unclear. Here we have evaluated the expression of H2S producing enzymes as well as the effect of endogenous and exogenous H2S on human bladder UC cells. In human UC cells
Diallyl Trisulfide, the Antifungal Component of Garlic Essential Oil and the Bioactivity of Its Nanoemulsions Formed by Spontaneous Emulsification.
Gong, et al.
Molecules (Basel), 26 (2022)
Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role.
Jeremic, et al.
International Journal of Molecular Sciences, 21 (2021)
RamaRao Malla et al.
Journal of pharmaceutical analysis, 12(2), 221-231 (2022-05-19)
Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. It is a cancer that originates from the mammary ducts and involves mutations in multiple genes. Recently, the treatment of breast cancer has become increasingly challenging
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