推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
技术
HPLC: suitable
颜色
white to yellow
储存温度
−20°C
SMILES字符串
COC1=CC(OC)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2
InChI
1S/C18H20O4/c1-19-15-8-7-14(18(12-15)22-4)6-5-13-9-16(20-2)11-17(10-13)21-3/h5-12H,1-4H3/b6-5+
InChI key
JDBCWSHYEQUBLW-AATRIKPKSA-N
生化/生理作用
2,3′,4,5′-Tetramethoxystilbene, also known as TMS, is a selective and competitive inhibitor of cytochrome P450 1B. It is a synthetic trans-stilbene analog. TMS is an analog of resveratrol and is an anti-cancer agent. TMS is cytotoxic to gefitinib-resistant (G-R) non-small-cell lung cancer (NSCLC) cells. It binds to sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and promotes apoptosis and autophagy. TMS is also a selective inhibitor of CYP1B1.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Modulation of human cytochrome P450 1B1 expression by 2, 4, 3?, 5?-tetramethoxystilbene
Chun YJ, et al.
Drug Metabolism and Disposition, 33(12), 1771-1776 (2005)
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis
Chun YJ, et al.
Cancer Research, 61(22), 8164-8170 (2001)
The resveratrol analogue, 2, 3?, 4, 5?-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo [a] pyrene-DNA adduct formation in MCF-7 cells exposed to benzo [a] pyrene
Einem Lindeman T, et al.
Mutagenesis, 26(5), 629-635 (2011)
(Z) 3, 4, 5, 4?-trans-tetramethoxystilbene, a new analogue of resveratrol, inhibits gefitinb-resistant non-small cell lung cancer via selectively elevating intracellular calcium level
Fan XX, et al.
Scientific Reports, 5, 16348-16348 (2015)
Maria Tsachaki et al.
Cellular and molecular life sciences : CMLS, 77(6), 1153-1175 (2019-07-16)
Metabolic reprogramming of tumor cells involves upregulation of fatty acid (FA) synthesis to support high bioenergetic demands and membrane synthesis. This has been shown for cytosolic synthesis of FAs with up to 16 carbon atoms. Synthesis of long-chain fatty acids
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