SMB00378
二烯丙基二硫
≥98% (HPLC)
别名:
烯丙基二硫醚, 二烯丙基二硫
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线性分子式:
CH2=CHCH2SSCH2CH=CH2
化学文摘社编号:
分子量:
146.27
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
EC Number:
218-548-6
Beilstein/REAXYS Number:
1699241
MDL number:
产品名称
二烯丙基二硫, ≥98% (HPLC)
biological source
Allium sativum L.
InChI
1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
InChI key
PFRGXCVKLLPLIP-UHFFFAOYSA-N
SMILES string
C=CCSSCC=C
vapor density
>5 (vs air)
vapor pressure
1 mmHg ( 20 °C)
assay
≥98% (HPLC)
form
oil
color
colorless to yellow
refractive index
n20/D 1.541 (lit.)
bp
180-195 °C (lit.)
density
1.008 g/mL at 25 °C (lit.)
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Quality Level
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Application
二烯丙基二硫已用于：
- 研究其对不同神经胶质瘤细胞系凋亡诱导和细胞活力的影响
- 作为处理试剂和阳性对照，评估核因子E2相关因子(Nrf2)对乳腺癌细胞的抗炎调节作用
- 作为可用底物，检测乙酸铅/硫化铅方法的硫化氢(H2S)生成
Biochem/physiol Actions
二烯丙基二硫是一种强效抗癌剂。可减少致癌物诱导癌症，在体内和体外模型中均具有抗增殖活性。二烯丙基二硫(DADS)可增强绿茶对高脂高糖(HF/HS)喂养小鼠的抗肥胖和抗炎活性。还具有抗氧化、抗微生物、心血管保护和神经保护活性。二烯丙基二硫(DADS)具有抗有丝分裂和抗肿瘤作用，可抑制体内结肠肿瘤性病变的有丝分裂和体外实验中结肠肿瘤细胞生长。
天然存在于大蒜中的有机硫化合物。使蒜泥发出刺鼻的气味。抗癌药物，并可能提供对心血管疾病的保护。
General description
二烯丙基二硫(DADS)是一种油溶性挥发性有机硫化物，天然存在于大蒜(Allium sativum)中。化学结构简单，由两个硫原子与两个烯丙基连接而成。该成分是大蒜辣味的来源。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
143.6 °F - closed cup
flash_point_c
62 °C - closed cup
Jaehoon Bae et al.
The Journal of nutritional biochemistry, 64, 152-161 (2018-12-06)
Obesity is a major problem in developed countries and a burden on social health care systems. Several epidemiological studies showed the protective effects of green tea against obesity-related diseases. Cyclic guanosine monophosphate (cGMP) acts as a mediator for the physiological
Xiuxiu Song et al.
Evidence-based complementary and alternative medicine : eCAM, 2021, 5103626-5103626 (2021-11-09)
Garlic is widely accepted as a functional food and an excellent source of pharmacologically active ingredients. Diallyl disulfide (DADS), a major bioactive component of garlic, has several beneficial biological functions, including anti-inflammatory, antioxidant, antimicrobial, cardiovascular protective, neuroprotective, and anticancer activities.
Anna Choromanska et al.
Biomedical reports, 13(4), 32-32 (2020-08-18)
Gliomas are a group of malignant brain tumors. Despite significant efforts to optimize treatment options for patients with high-grade glioma, the prognosis of the overwhelming majority of patients remain poor. This bleak prognosis despite treatment of the glioma, is partly
V Robert et al.
Carcinogenesis, 22(8), 1155-1161 (2001-07-27)
Diallyl disulfide (DADS) is a major organosulphur compound present in garlic with an anti-mitotic potential against colon neoplastic lesions in vivo and colon tumour cell growth in vitro. Using the human colon adenocarcinoma HT-29 Glc(-/+) cell line we identified sub-populations
Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations.
Robert V, et al.
Carcinogenesis, 22(8), 1155-1161 (2001)
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