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质量水平
检测方案
≥96% (HPLC)
形式
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O
InChI
1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3
InChI key
LBTVHXHERHESKG-UHFFFAOYSA-N
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一般描述
四氢姜黄素(THC)是姜黄素的无色代谢产物。结构与姜黄素类似。THC的化学结构中不含α, β-不饱和羰基。是来源于莪术(Curcuma zedoaria)、姜笋(Zingiber mioga)和姜(Zingiber officinale)根部的天然产物。
应用
四氢姜黄素(THC)已作为神经保护剂,研究其在缺血性中风小鼠模型中改善线粒体功能障碍的治疗潜力。
生化/生理作用
四氢姜黄素的治癌作用经过充分研究,具有出色的抗癌、抗血管生成和化学预防活性。还具有抗炎性。已发现四氢姜黄素可通过缓解氧化应激发挥针对糖尿病和血管功能障碍的抗氧化和保护作用。
WGK
WGK 3
闪点(°F)
385.2 °F
闪点(°C)
196.2 °C
Molecules (Basel, Switzerland), 20(1), 185-205 (2014-12-31)
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin.
Neurochemistry international, 122, 120-138 (2018-11-26)
The objectives of this study are to identify the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion (I/R) injury and the therapeutic potential of tetrahydrocurcumin (THC) to mitigate mitochondrial dysfunction in experimental stroke model. In our study, 8-10 weeks old male
The Tohoku journal of experimental medicine, 239(1), 25-38 (2016-05-07)
Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and
Biomolecules, 10(6) (2020-06-04)
In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field
Food & function, 5(1), 12-17 (2013-11-14)
Chemoprevention is a relatively new and promising strategy to prevent human degenerative diseases, including cancer, and is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the progress of human diseases. Tetrahydrocurcumin
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