所有图片(1)
About This Item
经验公式（希尔记法）:
C16H9NO6
CAS号:
分子量:
311.25
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.25
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方案
≥97% (HPLC)
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
SMILES字符串
OC(C1=C2C([N+]([O-])=O)=CC3=CC=CC=C3C2=C4OCOC4=C1)=O
InChI
1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
InChI key
MEEXETVZNQYRSP-UHFFFAOYSA-N
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一般描述
马兜铃酸B或称马兜铃酸II （AA-II）是马兜铃科植物叶、根和茎中含量最丰富的次级代谢产物之一。AA-II 结构类似于马兜铃酸I（AA-I)），唯一差别在于C8上的甲氧基。
应用
马兜铃酸B可用于测试其对贵腐霉菌（Botrytis cinerea）的真菌毒性作用。它也已用作参考标准品，用于通过高效液相色谱/电喷雾电离质谱（HPLC/ESI-MS）研究其对体内代谢的作用。
生化/生理作用
马兜铃酸B能够以剂量依赖性的方式通过HSF-PLA2对体外磷脂的水解进行抑制。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2 Inhalation - Muta. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
R Melo et al.
Letters in applied microbiology, 68(1), 48-55 (2018-10-17)
The fungitoxic effect of aristolochic acids I and II on mycelial growth and conidial germination of Botrytis cinerea was analysed. Aristolochic acid I had a higher effect on mycelial growth of B. cinerea than aristolochic acid II with IC50 value
Alena Dedı Ková et al.
Chemical research in toxicology, 33(11), 2804-2818 (2020-09-08)
The plant extract aristolochic acid (AA), containing aristolochic acid I (AAI) and II (AAII) as major components, causes aristolochic acid nephropathy and Balkan endemic nephropathy, unique renal diseases associated with upper urothelial cancer. Differences in the metabolic activation and detoxification
Sivaprasad Attaluri et al.
Nucleic acids research, 38(1), 339-352 (2009-10-27)
Aristolochic acids I and II (AA-I, AA-II) are found in all Aristolochia species. Ingestion of these acids either in the form of herbal remedies or as contaminated wheat flour causes a dose-dependent chronic kidney failure characterized by renal tubulointerstitial fibrosis.
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