推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
InChI
1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
QMQIQBOGXYYATH-IDABPMKMSA-N
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一般描述
Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.
应用
Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.
生化/生理作用
Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Low-frequency components of cardiovascular variabilities as markers of sympathetic modulation.
M Pagani et al.
Trends in pharmacological sciences, 13(2), 50-54 (1992-02-01)
Zhiwang Song et al.
Oncology reports, 43(2), 516-524 (2020-01-03)
Pancreatic cancer is characterized by aggressive and highly metastatic phenotypes. This disease exhibits a poor patient prognosis and is considered a challenge due to the limited treatment options encountered in clinical practice. Previous studies have shown that ruscogenin, a saponin
Hexin Wen et al.
Oxidative medicine and cellular longevity, 2022, 4877275-4877275 (2022-03-22)
Interaction of intestinal barrier dysfunction and intestinal inflammation promotes the progression of Crohn's disease (CD). A more recent study has suggested that ruscogenins (RUS) can exert anti-inflammatory effects through activation of the Nrf2/NQO1 pathway. The current study is aimed at
J Vermeiren et al.
Acta orthopaedica Belgica, 58(1), 88-90 (1992-01-01)
Partial and sometimes full-thickness rotator cuff tears can be managed by arthroscopic debridement and anterior acromioplasty. The recent literature on shoulder arthroscopy does not however mention any alternative operation techniques for this very common lesion. We present a case of
Ya-Lin Huang et al.
Journal of pharmacological sciences, 108(2), 198-205 (2008-10-24)
Ruscogenin (RUS), first isolated from Ruscus aculeatus, also a major steroidal sapogenin of traditional Chinese herb Radix Ophiopogon japonicus, has been found to exert significant anti-inflammatory and anti-thrombotic activities. Our previous studies suggested that ruscogenin remarkably inhibited adhesion of leukocytes
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