检测方案
≥95% (LC/MS-ELSD)
形式
solid
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
CC(O)CCc1ccc(O)cc1
InChI
1S/C10H14O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-8,11-12H,2-3H2,1H3
InChI key
SFUCGABQOMYVJW-UHFFFAOYSA-N
一般描述
Natural product derived from plant source.
生化/生理作用
Rhododendrol is a natural phenolic compound that has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes in male mice. RK has shown potential to increase dermal IGF-I production through sensory neuron activation, promoting hair growth and increasing skin elasticity.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Rie Takagi et al.
Dermatology (Basel, Switzerland), 232(1), 44-49 (2015-11-28)
Rhododendrol, a phenolic compound contained in lightening/whitening cosmetics, can bind and inhibit tyrosinase and was reported to induce leukoderma in Japan. Only 2% of the cosmetics users are affected, and tacrolimus is effective in treatment of the condition. To test
Yu Gabe et al.
Journal of dermatological science, 91(3), 311-316 (2018-07-15)
Rhododendrol (4-(4-hydroxyphenyl)-2-butanol) has been used as a lightening/whitening cosmetic but was recently reported to induce leukoderma. Although rhododendrol has been shown to be transformed by tyrosinase to hydroxyl-rhododendrol, which is cytotoxic to melanocytes, its detailed mechanism of action including the
Masatoshi Kondo et al.
Pigment cell & melanoma research, 29(5), 541-549 (2016-05-26)
Rhododendrol is a phenolic compound that shows a tyrosinase-dependent toxicity for melanocytes and occasionally induces a vitiligo-like skin depigmentation. The post-tyrosinase mechanisms determining melanocyte death or survival, however, are far from clear. Here, we find that rhododendrol treatment leads to
Minoru Sasaki et al.
Pigment cell & melanoma research, 27(5), 754-763 (2014-06-04)
Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of repeated chemical contact. Rhododendrol competitively inhibited mushroom tyrosinase and served as a good substrate, while it also
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