推荐产品
一般描述
我们全面的shRNA产品系列包括超过150,000个预克隆的shRNA构建体，靶向超过15,000个人类基因和15,000个小鼠基因。该文库可用于：基因家族集合：与特定功能类（如激酶和离子通道）相关的基因集合；基因靶标集合，针对靶标基因的shRNA克隆集合；以及单个shRNA克隆。我们的shRNA和慢病毒制造平台利用专门实验室，配备最先进的机器人技术、液体处理和实验室信息管理系统（LIMS），为您的RNAi研究需求提供卓越的质量和服务。
MISSION® TRC shRNA bacterial glycerol stocks offer a renewable resource for shRNA plasmids. These plasmids can then be transfected directly, or packaged into lentiviral particles.
应用
MISSION® shRNA has been used in the generation of damage-regulated autophagy modulator (DRAM) and p73 knockdown cell lines. It has also been used in lentivirus generation and gene knockdown and to investigate the contribution of PAX8 (paired box 8) in ovarian cancer progression.
其他说明
想要查看实验方案和应用数据，请访问 sigma.com/shrna。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
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法规信息
新产品
Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma
Huang Y, et al.
Blood, 125(9), 1435-1443 (2015)
Nicola Currey et al.
Cellular and molecular gastroenterology and hepatology, 7(4), 819-839 (2019-03-05)
The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in precancerous lesions or polyps is not known. Here
Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells
Humbert M, et al.
Leukemia Research, 36(12), 1552-1556 (2012)
A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells
Di P, et al.
BMC Cancer, 14(1), 292-292 (2014)
Natalia Oleinik et al.
Science advances, 5(9), eaax1978-eaax1978 (2019-09-20)
How lipid metabolism is regulated at the outer mitochondrial membrane (OMM) for transducing stress signaling remains largely unknown. We show here that this process is controlled by trafficking of ceramide synthase 1 (CerS1) from the endoplasmic reticulum (ER) to the
商品
MISSION shRNA reduce the expression of specific target genes by targeting the specific mRNA therefore reducing the corresponding protein expression.
RNAi Consortium (TRC): Collaborative effort among academic labs and biotech/pharma institutes advancing RNA interference research.
相关内容
Find shRNAs for Individual Genes. Over 150,000 pre-cloned shRNA constructs targeting more than 15,000 human and 15,000 mouse genes.
寻找单独基因的shRNA超过150,000个预克隆的shRNA构建体，靶向超过15,000个人类基因和15,000个小鼠基因。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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