检测方案
≥95% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥65%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Thr-Phe-Leu-Leu-Arg-NH2
应用
PAR-1 selective agonist has been used for platelet aggregation.
Thr-Phe-Leu-Leu-Arg-NH2 (TFLLR-NH2) is used as a selective agonist for protease-activated receptor 1 (PAR1) which is involved in the development of cardiac remodeling and hypertrophy after myocardial injury.
生化/生理作用
Protease-activated receptor-1 (PAR-1) is a G protein-coupled receptor, that is activated through thrombin and other proteases.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK
Uematsu K, et al.
Cellular Physiology and Biochemistry, 49(4), 1523-1538 (2018)
High-resolution crystal structure of human protease-activated receptor 1
Zhang C, et al.
Nature, 492(7429), 387-387 (2012)
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