所有图片(1)

文件

COO原产地证书/COA分析证书

SCP0212

PKA Substrate

Name: PKA Substrate
Brand: SIGMA

≥95% (HPLC), lyophilized

登录查看公司和协议定价

所有图片(1)

About This Item

经验公式（希尔记法）:

C₃₉H₇₄N₂₀O₁₂

分子量:

1015.13

UNSPSC代码:

12352204

NACRES:

NA.32

product name

PKA Substrate,

检测方案

≥95% (HPLC)

形式

lyophilized

组成

Peptide Content, ≥60%

储存条件

protect from light

储存温度

−20°C

Amino Acid Sequence

Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ser-Ile-NH2

一般描述

cAMP-dependent protein kinase (PKA) Substrate (GRTGRRNSI-NH2) is a nine amino acid phosphorylatable substrate of cyclic adenosine monophosphate (cAMP)-dependent protein kinase.

应用

cAMP-dependent protein kinase (PKA) Substrate has been used as a peptide substrate for Plasmodium cyclic guanosine monophosphate (GMP)-dependent protein kinase in enzymatic assay and inhibition assay. It has also been used as a positive control in the in vitro protein kinase A (PKA) phosphorylation assay.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop.

Michael J Moore et al.

The Journal of biological chemistry, 278(12), 10613-10618 (2002-12-25)

For optimal activity the catalytic subunit of cAMP-dependent protein kinase requires a phosphate on Thr-197. This phosphate anchors the activation loop in the proper conformation and contributes to catalytic efficiency by enhancing the phosphoryl transfer rate and increasing the affinity

Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p.

Jacqueline B Pierce et al.

Eukaryotic cell, 13(2), 209-230 (2013-12-04)

The two main signal transduction mechanisms that allow eukaryotes to sense and respond to changes in glucose availability in the environment are the cyclic AMP (cAMP)/protein kinase A (PKA) and AMP-activated protein kinase (AMPK)/Snf1 kinase-dependent pathways. Previous studies have shown

Insights into nucleotide binding in protein kinase A using fluorescent adenosine derivatives.

Q Ni et al.

Protein science : a publication of the Protein Society, 9(9), 1818-1827 (2000-10-25)

The binding of the methylanthraniloyl derivatives of ATP (mant-ATP), ADP (mant-ADP), 2'deoxyATP (mant-2'deoxyATP), and 3'deoxyATP (mant-3'deoxyATP) to the catalytic subunit of protein kinase A was studied to gain insights into the mechanism of nucleotide binding. The binding of the mant

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites.

Maria Penzo et al.

Scientific reports, 9(1), 7005-7005 (2019-05-09)

Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental stages. An imidazopyridine PKG inhibitor scaffold

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.

Manu Vanaerschot et al.

Cell chemical biology, 27(7), 806-816 (2020-05-04)

The search for antimalarial chemotypes with modes of action unrelated to existing drugs has intensified with the recent failure of first-line therapies across Southeast Asia. Here, we show that the trisubstituted imidazole MMV030084 potently inhibits hepatocyte invasion by Plasmodium sporozoites

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

文件