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Merck
CN
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文件

安全信息

SCP0188

Sigma-Aldrich

MMP 8 Substrate

≥95% (HPLC), lyophilized

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About This Item

经验公式（希尔记法）:
C49H63N13O13
分子量:
1042.10
UNSPSC代码:
12352200
NACRES:
NA.32

product name

MMP 8 Substrate, ≥95% (HPLC)

检测方案

≥95% (HPLC)

形式

lyophilized

组成

Peptide Content, ≥80%

储存条件

protect from light

储存温度

−20°C

Amino Acid Sequence

DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg

应用

Matrix metalloproteinases (MMP) are a family of zinc-dependent endopeptidases that degrade matrix proteins. MMPs include collagenases, gelatinases, matrilysins, enamelysins, metalloelastases, stromelysins and other structural protein and receptor lysins. The activity of these enzymes is selectively inhibited or measured by appropriately labeled peptides. DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg (DNP-PLAYWAR) is used as a fluorogenic substrate for matrix metalloprotein-8 (MMP-8).

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How is product SCP0188, MMP 8 Substrate, used for detecting MMP-8 activity?

    The use of DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg as a fluorogenic substrate in measuring the activity of human neutrophil collagenase (MMP-8) is described in Netzel-Arnett, S., et al., Continuously recordingfluorescent assays optimized for five human matrix metalloproteinases. Anal. Biochem., 195, 86-92 (1991).

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