product name
HIV-TAT (48-57),
检测方案
≥95% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥55%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH2
一般描述
人类免疫缺陷病毒（HIV）-转录反式激活因子（Tat）是一种调节蛋白，由 HIV-1 的 Tat 基因编码。Tat 由两个外显子、高度保守区域和亚型特异性区域组成。
生化/生理作用
人类免疫缺陷病毒（HIV）-转录反式激活因子（Tat）参与HIV相关并发症的发病机理。Tat 蛋白还与 HIV 相关的心功能障碍有关。HIV-TAT（48-57）用于促进合成肽的内化。
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Yanan Jiang et al.
Journal of translational medicine, 16(1), 121-121 (2018-05-10)
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which
S-M Lee et al.
Clinical and experimental immunology, 161(3), 504-511 (2010-07-22)
The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a
S-M Lee et al.
Clinical and experimental immunology, 167(3), 438-446 (2012-02-01)
The immune receptor expressed on myeloid cells 1 (IREM-1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM-1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). In
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