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Merck
CN
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文件

安全信息

SCP0138

Sigma-Aldrich

BQ-3020

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别名:
Acetyl-(Ala 11,15)-ET 1 (6-21), Acetyl-[Ala 11,15]-endothelin 1 (6-21), BQ 3020, endothelin receptor agonist
经验公式（希尔记法）:
C96H140N20O25S1
CAS号:
143113-45-5
分子量:
2006.32
UNSPSC代码:
12352200
NACRES:
NA.32

检测方案

≥95% (HPLC)

形式

lyophilized

组成

Peptide Content, ≥75%

储存条件

protect from light

UniProt登记号

P05305

储存温度

−20°C

InChI

1S/C93H136N20O23S/c1-15-51(9)77(91(133)110-72(93(135)136)40-58-44-96-62-27-21-20-26-61(58)62)113-92(134)78(52(10)16-2)112-89(131)71(43-75(119)120)108-85(127)66(37-49(5)6)105-87(129)69(41-59-45-95-47-98-59)104-79(121)54(12)100-83(125)67(38-56-24-18-17-19-25-56)106-86(128)68(39-57-29-31-60(115)32-30-57)109-90(132)76(50(7)8)111-80(122)53(11)99-73(116)46-97-81(123)63(28-22-23-34-94)102-88(130)70(42-74(117)118)107-82(124)64(33-35-137-14)103-84(126)65(36-48(3)4)101-55(13)114/h17-21,24-27,29-32,44-45,47-54,63-72,76-78,96,115H,15-16,22-23,28,33-43,46,94H2,1-14H3,(H,95,98)(H,97,123)(H,99,116)(H,100,125)(H,101,114)(H,102,130)(H,103,126)(H,104,121)(H,105,129)(H,106,128)(H,107,124)(H,108,127)(H,109,132)(H,110,133)(H,111,122)(H,112,131)(H,113,134)(H,117,118)(H,119,120)(H,135,136)/t51-,52-,53-,54-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,76-,77-,78-/m0/s1

InChI key

NUAGCEFLVCODRQ-KETPNHLCSA-N

基因信息

human ... EDN1(1906)

Amino Acid Sequence

Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

生化/生理作用

BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors.
Ihara M
Life Sciences, 51(6) (1992)
A. Bjorklund
Peptides (New York, NY, United States) (2000)
Paola G Andreis et al.
Peptides, 23(3), 561-566 (2002-02-12)
Evidence has been provided that the 21-amino acid hypertensive peptide endothelin (ET)-1 exerts a potent secretagogue effect on human adrenocortical zona glomerulosa (ZG), acting through two receptor subtypes, called ET(A) and ET(B), the signaling mechanism(s) of which has (have) not
Ana Sánchez et al.
European journal of pharmacology, 640(1-3), 190-196 (2010-05-25)
Since endothelin-1 (ET-1) is involved in prostatic disorders, the current study investigated the mechanisms underlying the ET-1-induced effects in pig prostatic small arteries. The experiments were performed in rings mounted in microvascular myographs containing physiological saline solution at 37oC for
Jörg Kleeberg et al.
American journal of physiology. Heart and circulatory physiology, 286(4), H1339-H1346 (2003-12-06)
Recently, it has been shown that brain topical superfusion of endothelin (ET)-1 at concentrations around 100 nM induces repetitive cortical spreading depressions (CSDs) in vivo. It has remained unclear whether this effect of ET-1 is related to a primary neuronal/astroglial
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