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Merck
CN
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主要文件

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安全信息

SCP0138

Sigma-Aldrich

BQ-3020

别名:

Acetyl-(Ala 11,15)-ET 1 (6-21), Acetyl-[Ala 11,15]-endothelin 1 (6-21), BQ 3020, endothelin receptor agonist

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About This Item

经验公式（希尔记法）:
C96H140N20O25S1
CAS号:
143113-45-5
分子量:
2006.32
UNSPSC代码:
12352200
NACRES:
NA.32

方案

≥95% (HPLC)

表单

lyophilized

组成

Peptide Content, ≥75%

储存条件

protect from light

UniProt登记号

P05305

储存温度

−20°C

SMILES字符串

S(CC[C@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc5ccc(cc5)O)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3[nH]cnc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N

InChI

1S/C93H136N20O23S/c1-15-51(9)77(91(133)110-72(93(135)136)40-58-44-96-62-27-21-20-26-61(58)62)113-92(134)78(52(10)16-2)112-89(131)71(43-75(119)120)108-85(127)66(37-49(5)6)105-87(129)69(41-59-45-95-47-98-59)104-79(121)54(12)100-83(125)67(38-56-24-18-17-19-25-56)106-86(128)68(39-57-29-31-60(115)32-30-57)109-90(132)76(50(7)8)111-80(122)53(11)99-73(116)46-97-81(123)63(28-22-23-34-94)102-88(130)70(42-74(117)118)107-82(124)64(33-35-137-14)103-84(126)65(36-48(3)4)101-55(13)114/h17-21,24-27,29-32,44-45,47-54,63-72,76-78,96,115H,15-16,22-23,28,33-43,46,94H2,1-14H3,(H,95,98)(H,97,123)(H,99,116)(H,100,125)(H,101,114)(H,102,130)(H,103,126)(H,104,121)(H,105,129)(H,106,128)(H,107,124)(H,108,127)(H,109,132)(H,110,133)(H,111,122)(H,112,131)(H,113,134)(H,117,118)(H,119,120)(H,135,136)/t51-,52-,53-,54-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,76-,77-,78-/m0/s1

InChI key

NUAGCEFLVCODRQ-KETPNHLCSA-N

基因信息

human ... EDN1(1906)

Amino Acid Sequence

Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

生化/生理作用

BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BB0159

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A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors.
Ihara M
Life Sciences, 51(6) (1992)
Phuong N Quang et al.
Pain, 149(2), 254-262 (2010-03-09)
Endothelin-1 (ET-1) produced by various cancers is known to be responsible for inducing pain. While ET-1 binding to ETAR on peripheral nerves clearly mediates nociception, effects from binding to ETBR are less clear. The present study assessed the effects of
Q T Nguyen et al.
Circulation, 104(17), 2075-2081 (2001-10-24)
Some controversy exists as to the effects of endothelin (ET) receptor antagonism on long-term post-myocardial infarction (MI) evolution, particularly as it relates to the timing of the intervention after MI (<24 hours versus 10 days). Sham rats and rats surviving
Peter Johnström et al.
Experimental biology and medicine (Maywood, N.J.), 231(6), 736-740 (2006-06-03)
The endothelin (ET) receptor system has been shown to play a role in a number of vascular diseases. We have synthesized 18F-and 11C-labeled radioligands to enable in vivo imaging of the fundamental processes involved in ET receptor pharmacology in normal
A. Bjorklund
Peptides (New York, NY, United States) (2000)
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