检测方案
≥95% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥80%
储存条件
protect from light
溶解性
1 mg/mL at in water (Add acetonitrile dropwise to solution in water, mixing until the peptide dissolves)
储存温度
−20°C
Amino Acid Sequence
Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
应用
IRL-1620 is used as a specific endothelin-B receptor (ET(B)-R) agonist.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Mary G Leonard et al.
Brain research, 1420, 48-58 (2011-10-01)
Endothelin and its receptors have long been considered therapeutic targets in the treatment of ischemic stroke. Recent studies indicate that ET(B) receptors may provide both vasodilatation and neuroprotection. The purpose of this study was to determine the effect of selectively
A Gulati et al.
Arzneimittel-Forschung, 62(1), 14-17 (2012-02-15)
ETB receptor agonist, IRL-1620 (or SPI-1620) presently in US Phase 1 clinical trial, has been demonstrated to selectively and transiently increase tumor blood flow. The present study was conducted to determine the effect of IRL-1620 on radiation therapy in tumor
Fernando S Carneiro et al.
The journal of sexual medicine, 5(12), 2793-2807 (2008-10-01)
The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive forms of hypertension, we hypothesized that activation
Manish S Lavhale et al.
Pharmacological research, 62(6), 489-499 (2010-09-10)
Clonidine decreases mean arterial pressure (MAP) by acting as an α(2)-adrenergic receptor (AR) agonist in the central nervous system; it also acts on peripheral α-ARs to produce vasoconstriction. Endothelin (ET) has been shown to modulate the action of ARs. The
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