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Merck
CN
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主要文件

安全信息

SCP0123

Sigma-Aldrich

[D-Gln4]-Desmopressin

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About This Item

经验公式（希尔记法）:
C46H64N14O12S2
分子量:
1069.22
UNSPSC代码:
12352209
NACRES:
NA.32

方案

≥95% (HPLC)

表单

lyophilized

组成

Peptide Content, ≥75%

储存条件

protect from light

储存温度

−20°C

Amino Acid Sequence

Mpa-Tyr-Phe-D-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2

应用

Desmopressin is a synthetic alternative to arginine vasopressin that acts via V2 receptors in renal collecting ducts to regulate water retention. [D-Gln4]-Desmopressin may be used in studies of conformations and receptor activity of desmopressin analogues.

生化/生理作用

Desmopressin is considered safe for consumption during first and second trimesters of pregnancy. But, it shows high risk of arterial thrombosis. It is known to induce platelet factor VIII and VWF (Von Willebrand factor) and improves platelet aggregation. Desmopressin is found helpful in congenital bleeding disorder.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
E278006
BH0512

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Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 63-63 (2014)
Mattias Hedenström et al.
Journal of medicinal chemistry, 45(12), 2501-2511 (2002-05-31)
Three analogues of the antidiuretic drug desmopressin ([1-desamino,8-D-arginine]vasopressin) have been prepared. In two of these, gamma-turn mimetics based on a morpholin-3-one framework have been inserted instead of residues Phe3-Asn5, whereas the third analogue has a methylene ether isostere in place
Platelets, 1243-1243 (2011)
J Wang et al.
International journal of peptide and protein research, 45(5), 471-481 (1995-05-01)
The solution structures of desmopressin, a nine-residue peptide with specific antidiuretic and antibleeding activities, have been studied in aqueous and TFE-containing solutions by two-dimensional NMR and molecular modeling techniques. It is found that TFE induces a conformational change of the

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