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Merck
CN

SCP0110

组织蛋白酶抑制剂

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关于此项目

经验公式（希尔记法）:
C35H59N11O5
分子量:
713.91
NACRES:
NA.32
UNSPSC Code:
12352200

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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥55%

storage condition

protect from light

storage temp.

−20°C

相关类别

Application

组织蛋白酶L是一种可代谢胶原蛋白和弹性蛋白的溶酶体半胱氨酸蛋白酶。组织蛋白酶L的作用和活性可借助肽抑制剂如五肽酰胺RKLLW-NH2（Arg-Lys-Leu-Leu-Trp-NH2）而得以研究。

General description

组织蛋白酶L抑制剂是一种组蛋白H3加工酶。它在维持表皮稳态、毛囊正常形态发生和周期中起重要作用。组织蛋白酶L参与蛋白降解。它可能会调节免疫系统的正常功能。组织蛋白酶L可调节巨噬细胞死亡、坏死核心形成和动脉粥样硬化斑块不稳定进展。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
E1273
CN0623

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Do you have any references for product SCP0110, Cathepsin L Inhibitor?

    Product SCP0110, Cathepsin L inhibitor peptide has the sequence Arg-Lys-Leu-Leu-Trp-NH2, which can be abbreviated RKLLW-NH2.See the following paper for reference: A. Brinker, et al.: Eur. J. Biochem., 267(16), 5085-5092 (2000). Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

A Brinker et al.
European journal of biochemistry, 267(16), 5085-5092 (2000-08-10)
By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells
Liu J, et al.
Atherosclerosis, 184(2), 302-311 (2006)
Protease signalling: the cutting edge
Turk B, et al.
The Embo Journal, 31(7), 1630-1643 (2012)
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Li W, et al.
Atherosclerosis, 202(1), 92-102 (2009)
V Turk et al.
The EMBO journal, 20(17), 4629-4633 (2001-09-05)
From their discovery in the first half of the 20th century, lysosomal cysteine proteases have come a long way: from being the enzymes non-selectively degrading proteins in lysosomes to being those responsible for a number of important cellular processes. Some
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