product name
Caspase1 Substrate,
检测方案
≥95% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥85%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
MCA-Tyr-Val-Ala-Asp-Ala-Pro-DNP-Lys
应用
Caspase 1 is a cysteine protease activator of inflammatory processes which may be detected using a variety of chromogenic and fluorogenic peptide substrates build around the VAD (val-ala-asp) or WEAD (trp-glu-ala-asp) sequences. These substrates include: Ac-VAD-pNa (acetyl-Val-Ala-Asp-p-nitroanalide), chromogenic; Ac-VAD-AFC (acetyl-Val-Ala-Asp-AFC), fluorogenic; Ac-VAD-4-methoxy-2-naphtylamide (acetyl-Val-Ala-Asp-4-methoxy-2-naphtylamide); Ac-WVAD-pNa (acetyl-Trp-Val-Ala-Asp-p-nitroanalide), chromogenic; Ac-WVAD-AMC (acetyl-Trp-Val-Ala-Asp-7-amino-4-methylcoumarin), fluorogenic; Ac-WEAD-pNA (acetyl-Trp-Glu-Ala-Asp-p-nitroanalide), chromogenic; Ac-WEAD-AMC (acetyl-Trp-Glu-Ala-Asp-7-amino-4-methylcoumarin), fluorogenic; and MCA-YVADAP-DNP-K (MCA-Tyr-Val-Ala-Asp-Ala-Pro-DNP-Lys).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Jerry Shen et al.
Atherosclerosis, 210(2), 422-429 (2010-01-12)
The preferred amino acids in the proteolytic sites have been considered to be similar between caspase-1 and caspase-9, which do not support their differential functions in inflammatory pyroptosis and apoptosis. We attempted to solve this problem. We analyzed the flanking
Annamaria Vezzani et al.
Current opinion in investigational drugs (London, England : 2000), 11(1), 43-50 (2010-01-05)
Epilepsy is a disabling neurological disorder that is characterized by recurring, unprovoked seizures. Drug-resistant epilepsy affects approximately 30% of individuals with epilepsy; thus, one of the main challenges for epilepsy therapy is the development of alternative anticonvulsant approaches. The discovery
Eve-Lyne Marchand et al.
Circulation research, 92(7), 777-784 (2003-03-08)
Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk)
F Martinon et al.
Cell death and differentiation, 14(1), 10-22 (2006-09-16)
Fifteen years have passed since the cloning and characterization of the interleukin-1beta-converting enzyme (ICE/caspase-1), the first identified member of a family of proteases currently known as caspases. Caspase-1 is the prototypical member of a subclass of caspases involved in cytokine
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