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检测方案
≥95% (HPLC)
形式
lyophilized
组成
Peptide Content, ≥85%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Ac-Asp-Glu-Val-Asp-7-AFC
应用
Ac-DEVD-7-AFC (N-acetyl-asp-glu-val-asp-7-amino-4-trifluoromethyl coumarin) is used as a cell penetrating fluorogenic CED-related caspase substrate.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Caspase activation by anticancer drugs: the caspase storm.
Tao Z, Goodisman J, Penefsky HS, et al.
Molecular Pharmacology, 4, 583-595 (2007)
Kateřina Kuželová et al.
Journal of cellular biochemistry, 112(11), 3334-3342 (2011-07-14)
The effects of the pan-caspase inhibitor Q-VD-OPh on caspase activity, DNA fragmentation, PARP cleavage, 7A6 exposition, and cellular adhesivity to fibronectin were analyzed in detail in three different apoptotic systems involving two cell lines (JURL-MK1 and HL60) and two apoptosis
Benjawan Wudtiwai et al.
Journal of hematology & oncology, 4, 52-52 (2011-12-22)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells, but does not affect normal cells or human leukemic cells, such as MOLT-4 and U937 cells, which are relatively resistant to TRAIL. Three flavonoids extracted from the rhizome
R A Jones et al.
Hepatology (Baltimore, Md.), 27(6), 1632-1642 (1998-06-10)
The mechanism of Fas antigen-induced hepatocyte apoptosis was investigated. Using a monoclonal antibody directed against the Fas antigen, apoptosis was induced in freshly isolated murine hepatocytes within 90 minutes of antibody addition as assessed by plasma membrane bleb formation, chromatin
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