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Merck
CN
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文件

安全信息

SCP0030

Sigma-Aldrich

[Gly22]-Amyloid β 1-42 Arctic human

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经验公式(希尔记法):
C200H307N55O58S1
分子量:
4441.98
UNSPSC代码:
12352209
NACRES:
NA.32

检测方案

≥95% (HPLC)

形式

lyophilized

组成

Peptide Content, ≥75%

储存条件

protect from light

UniProt登记号

储存温度

−20°C

基因信息

human ... APP(351)

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gly-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

一般描述

β-Amyloid 1-42 is one of the major constituents of the neurofibrillary tangles and plaques characteristic of the Alzheimer brain. The Arctic mutation E22G causes early onset of Alzheimer′s compared to wild type and promotes protofibril formation and neurotoxicity.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Qiujian Yu et al.
Biological research, 51(1), 35-35 (2018-09-21)
The previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive

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