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形式
solid
质量水平
比活
(Antibacterial)
溶解性
water: freely soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses
作用机制
protein synthesis | interferes
储存温度
−20°C
一般描述
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC). Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease. In addition, Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.
应用
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
生化/生理作用
Rifampicin inhibits the assembly of DNA and protein into mature virus particles. It inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase, which results in cell death.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. Inhibits the assembly of DNA and protein into mature virus particles.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles.
Peyret, Hadrien, et al
Recombinant proteins from plants: production and isolation of clinically useful compounds, 103-111 (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)
Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Tomohiro Umeda et al.
Biomedicines, 10(2), 297-297 (2022-02-26)
The cell-to-cell transmission of tau aggregates is considered a mechanism underlying the intracerebral spreading of tau pathology in Alzheimer's disease (AD) and other tauopathies. Recent studies suggest that tau oligomers, rather than fibrils, participate in this process. We previously showed
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