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SBR00065

Sigma-Aldrich

Rifampicin Ready Made Solution

50 mg/mL in DMSO

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About This Item

经验公式（希尔记法）:
C43H58N4O12
CAS号:
13292-46-1
分子量:
822.94
UNSPSC代码:
41116107
NACRES:
NA.76

表单

liquid

质量水平

200

比活

Antibacterial

浓度

50 mg/mL in DMSO

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

N5(CCN(CC5)C)\N=C\c1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C(=O)N2)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c1O)O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

一般描述

Rifampicin is a microlide antibiotic effective against gram-positive and gram-negative bacteria, mycobacteria and viruses.

应用

  • Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections.
  • Rifampicin is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, and primary biliary cirrhosis (PBC).
  • Rifampicin was also found active by inhibiting Tau Oligomer Propagation in Alzheimer’s disease.
  • Rifampicin is used as a selection agent for agrobacterium mediated plant transformation.

生化/生理作用

Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

其他说明

The product is supplied in DMSO at a concentration of 50 mg/mL. Working concentrations for agrobacterium selection are typically 10-50 mg/L.

危险声明

H362

危险分类

Lact.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000411085
0000411085
0000345737
0000328305
0000328305

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访问文档库

Guidelines for the Management of Cholestatic Liver Diseases (2021)
Lu, Lungen
Journal of clinical and translational hepatology (2022)
Specific packaging of custom RNA molecules into cowpea mosaic virus-like particles
Peyret, Hadrien, et al
Methods in Molecular Biology, 103-111 (2022)
Treatment of rifampicin-resistant tuberculosis disease and infection in children: key updates, challenges and opportunities
Howell, Pauline, et al.
Pathogens (Basel, Switzerland), 11.4, 381-381 (2022)
Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
Umeda, Tomohiro, et al
Biomedicines, 10.2, 297-297 (2022)

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