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文件

SBR00014

Sigma-Aldrich

达托霉素二甲基亚砜溶液

1 mg/mL in DMSO

别名:

N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone

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About This Item

经验公式（希尔记法）:
C72H101N17O26
CAS号:
103060-53-3
分子量:
1620.67
MDL编号:
MFCD28968054
UNSPSC代码:
51101500
NACRES:
NA.76

生物来源

Streptomyces roseosporus

质量水平

200

描述

Ready Made Solution

形式

liquid

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

浓度

1 mg/mL in DMSO

颜色

colorless to faint yellow

抗生素抗菌谱

Gram-positive bacteria

作用机制

DNA synthesis | interferes
protein synthesis | interferes

运输

dry ice

储存温度

−20°C

SMILES字符串

O=C(NCC(N[C@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NC1)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CCCCCCCCC)=O)=O)=O)=O)[C@@H](C)OC([C@H](CC(C4=C(N)C=CC=C4)=O)NC([C@@]([C@H](C)CC(O)=O)([H])NC(

InChI

1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35?,36-,37?,43+,44+,45+,46+,47+,48+,49+,50-,60+,61?/m1/s1

InChI key

DOAKLVKFURWEDJ-OFNKPWESSA-N

相关类别

生化/生理作用

Daptomycin is a natural cyclic lipopeptide antibiotic found in Streptomyces roseosporus. It is has been found to be effective in treating infections caused by aerobic Gram-positive bacteria. Daptomycin inhibits many antibiotic resistant strains such as methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA).

The mode of action of daptomycin is quite different from that of any other antibiotic. Daptomycin binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death.

包装

0.5ML

制备说明

The 1 mg/mL solution may be further diluted in an appropriate buffer prior to use. It is recommended that a fresh dilution be made on the day of use.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

WGK

WGK 1

闪点(°F)

188.6 °F

闪点(°C)

87 °C

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[Daptomycin: revitalizing a former drug due to the need of new active agents against grampositive multiresistant bacterias].
Hernandez Marti V, et al.
Revista Espanola de Quimioterapia : Publicacion Oficial de la Sociedad Espanola de Quimioterapia, 20, 261-276 (2007)
Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids.
He Y, et al.
Bioorganic & Medicinal Chemistry Letters, 22, 6248-6251 (2012)
Feng Wang et al.
Gene, 544(2), 208-215 (2014-04-29)
Daptomycin, a novel cyclic lipopeptide antibiotic against Gram-positive bacteria, is produced by Streptomyces roseosporus. Though its biosynthetic mechanism, structural shuffling and fermentation optimization have been extensively studied, little is understood about its production regulation at the transcriptional levels. Here we
Diixa Patel et al.
International journal of antimicrobial agents, 38(5), 442-446 (2011-08-16)
Daptomycin is highly active against Staphylococcus aureus, including multidrug-resistant strains and those with reduced susceptibility to vancomycin. However, daptomycin-non-susceptible (Dap(NS)) strains [minimum inhibitory concentration (MIC) >1mg/L] have been derived clinically and in vitro. The mechanism(s) by which this occurs is

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